Functional microspheres were prepared from poIy(ester-anhydride)s with allyl pendant groups, using a solvent removal technique. The poly(ester-anhydride)s were obtained by polycondensation of sebacic acid (SBA) and oligo(3-allyloxy-l,2-propylene succinate) terminated with carboxyl groups (OSAGE). The SBA and OSAGE content influenced the characteristics of poly(ester-anhydride)s and microspheres. The poly(ester-anhydride)s differed with their solubility and thermal properties as well as their degradation rate and mode. Stable microspheres with size in the range of 15-60 nm were obtained from poly(ester-anhydride)s containing more than 60% SBA. The microspheres obtained from po!y(ester-anhydride)s containing 60% SBA had tendency to aggregation. Microspheres were not obtained when content of SBA in poly(ester-anhydride)s was lower than 60%. All particles were spherical, however those prepared from polymers containing 90 or 80% SBA possessed smoother surfaces when compared to those prepared from poly(ester-anhydride)s containing 70 or 60% SBA. Ability of poIy(ester-anhydride)s to be formulated as microspheres would enable their eventual use in drug delivery systems.
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Methyl methacrylate (MMA) was transesterified with poly(ethy-lene glycol) monomethyl esters to yield four poly(ethylene glycol) monomethyl ether methacrylates (MPEGMA). The resulting monomethylacrylate monomers were used as stabilizing agents in dispersion polymerization of allyl methacrylate (AMA) or an AMA-MMA mixture. Functional microspheres were prepared and their preliminary characteristics is given.
PL
Metakrylan metylu (MMA) transestryfikowano monometylowymi eterami glikoli polioksyetylenowych (MPEG) o ciężarach cząsteczkowych mieszczących się w zakresie 550-5000. Otrzymano cztery metakrylany tych monometylowych eterów (MPEGMA), które w charakterze makromonomerów zastosowano jako czynniki stabilizujące w polimeryzacji dyspersyjnej metakrylanu allilu (AMA) lub w kopolimeryzacji mieszaniny AMA/MMA. Otrzymano mikrosfery funkcjonalne zawierające MPEGMA i podano ich wstępną charakterystykę (widma 1H-NMR i IR, mikrofotografie).
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