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Irreversible blocking of polar excitations on frog sciatic nerve using semiconductor pulse laser irradiation

Hirayama Y., Ishizuka S., Yamakawa T.

Journal of Automation Mobile Robotics and Intelligent Systems

2009

Vol. 3, No. 4

210-212

The final purpose of our research is to cripple the epileptogenic focus by laser irradiation. However, the effect of laser irradiation on brain nerves is not well known. In this paper, we observed laser irradiation to the transmission of action potential of a bullfrog sciatic nerve in the experiment. In addition the marginal amplitude of laser energy is obtained. The bullfrog nerve preparations were stimulated supramaximal intensity pulse. The pulse width and the pulse interval are 1 msec and 1 sec, respectively. A semiconductor pulse laser irradiation (the wavelength, the pulse width and the frequency are 808 nm, 990 µsec and 50 Hz, respectively) was employed until when the amplitude of the action potential decreases to 10 %. The laser light was irradiated to the portion between two electrode pairs for recording. The energy of the laser is variable between 13.9- 202.5 mJ/cm2. The laser irradiator is connected to an optical fiber whose diameter is 1 mm. The action potential of the sciatic nerve is observed at 1 day after in order to confirm irreversibility. The experiment was delivered by the laser pulse, the energy of which over 32.9 mJ/cm2. The peak of action potential was decreased gradually by laser irradiation with depending on the time of irradiation. The time to blocking is reciprocally proportional to laser energy. At a day after the experiment, the action potential was not recovered. This result shows the laser irradiation give irreversible blocking to polar excitations. We observed the frog sciatic nerve is damaged by laser irradiation. The results show a possibility that the epileptogenic focus can be crippled by laser irradiation. We are going to have more experiments and obtain important laser parameters. In the future, the experiment and the result are expanded using rat brain and applied human surgery.