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2 Engineering of Biomaterials

2 2012

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Influence of thin films of bioglass and hydroxyapatite mixture deposited by PLD method on bioactivity of foam titanium implants

Mróz W., Budner B., Załęczny R., Bombalska A., Niedzielski K., Łączka M., Ślósarczyk A., Cholewa-Kowalska K., Douglas T. E. L., Schwarze D.

Engineering of Biomaterials

2012

Vol. 15, no. 116-117 spec. iss.

148

The introduction of different bioelements into the structure of hydroxyapatite exerts a positive influence on the growth of new bone tissue. One such useful bioelement is silica, which possesses antibacterial properties and also acts as a factor regulating bone mineralization through stimulation of DNA to synthesize osteoblasts. Results of investigations into integration of foam titanium implants (FTI), with rabbit bone are presented. Two groups of implants were investigated: clean titanium implants produced by selective laser melting and FTI coated with a thin film of hydroxyapatite (HA) mixed with 10 wt. % of bioglass (BG) of A2 type (CaO- P2P-SiO2). Analysis of histopathology of implants' integration with bone were performed by staining using the triple chromatographic method of Masson - Goldner, planimetric analysis using the Kruskal - Wallis test, an ANOVA test and microtomography. Application of layers of the type HA+GH showed superior integration with bone than uncoated titanium implants.

In vivo application of foam titanium implants with magnesium-doped octacalcium phosphate and hydroxyapatite thin films deposited by PLD method

Mróz W., Budner B., Załęczny R., Prokopiuk A., Niedzielski K., Ślósarczyk A., Douglas T. E. L., Scharze D.

Engineering of Biomaterials

2012

Vol. 15, no. 116-117 spec. iss.

141

Results of investigations into integration of foam titanium implants (FTI), with rabbit bone are presented. Three groups of implants were examined: clean titanium implants produced by selective laser melting, FTI coated with a thin film of octacalcium phosphate (OCP), doped with 0.6 weight percent of Mg, deposited by pulsed laser deposition (PLD), and FTI with hydroxyapatite (HA) doped with 0.6 wt.% of Mg. Analysis of histopathology of implants' integration with bone were performed by staining using the triple chromatographic method of Masson - Goldner, pla- nimetric analysis using the Kruskal - Wallis test, an ANOVA test and microtomography. The best results were obtained for implants coated with HA, followed by those coated with OCP. Implants from these two groups showed superior integration with bone than uncoated titanium implants.