Wyniki wyszukiwania - BazTech

Ograniczanie wyników

1 Polish Journal of Chemistry

1 2005

Znaleziono wyników: 1

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: fluorenylium derivative

Sortuj według:

Ogranicz wyniki do:

Spectral Properties and DNA-binding Study of 6a, 12a-Diazadibenzo-[a,g]fluorenylium Derivative

Juskowiak B., Gałęzowska E., Kościelna H., Hermann T., Piotrowska K.

Polish Journal of Chemistry

2005

Vol. 79 / nr 5

831-844

The DNA binding affinity and anion effect on the aggregation of a G-quadruplex selective ligand, 6a,12a-diazadibenzo-[a,g]fluorenylium derivative, were studied by UV-Vis absorption, molecular modeling and fluorescence spectroscopy. The anion character and its concentration influenced the spectral properties of ligand aggregates. Observed spectral peculiarities were discussed in terms of the formation of H- and J-type aggregates. The DNA binding mode and affinity of the ligand depended on the salt concentration; preferential binding to G-quadruplexDNAwas clearly seen at higher salt concentration.