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1 Polish Journal of Chemistry

1 2009

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Synthesis, Characterization and Anti-inflammatory Activity of Some Organotin(IV) Complexes

Rehman W., Rehman S., Muhammad B., Shah S. T., Tauseef I., Guo C. -Y.

Polish Journal of Chemistry

2009

Vol. 83, nr 12

2043-2049

The synthesis and characterization of new coordination compounds of some organotin(IV) chlo rides with fexofenadine are reported; the ligand molecules appear to be bound to the tin atom through carbonyl oxygen atom. The structure of the synthesized compounds has been characterized by elemental analyses, and bonding in these complexes is discussed in terms of their IR, 1H NMR and through Mössbauer studies. The spectroscopic results obtained are in full agreement with the proposed 1:1 stoichiometry. The synthesized complexes have been screened for anti-inflammatory effect. The results obtained showed that triphenyltin(IV) derivatives of fexofenadine exhibited promising anti-inflammatory effect as compared to the other tin(IV) derivatives of the same ligand.