Wyniki wyszukiwania - BazTech

Ograniczanie wyników

Znaleziono wyników: 2

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: external beam radiation therapy

Sortuj według:

Ogranicz wyniki do:

Normal tissue objective (NTO) tool in Eclipse treatment planning system for dose distribution optimization

Indrayani Liza, Anam Choirul, Sutanto Heri, Subroto Rinarto, Dougherty Geoff

Polish Journal of Medical Physics and Engineering

2022

Vol. 28, Iss. 2

99--106

Introduction: The purpose of this study was to determine the best normal tissue objective (NTO) values based on the dose distribution from brain tumor radiation therapy. Material and methods: The NTO is a constraint provided by Eclipse to limit the dose to normal tissues by steepening the dose gradient. The multitude of NTO setting combinations necessitates optimal NTO settings. The Eclipse supports manual and automatic NTOs. Fifteen patients were re-planned using NTO priorities of 1, 50, 100, 150, 200, and 500 in combination with dose fall-offs of 0.05, 0.1, 0.2, 0.3, 0.5, 1 and 5 mm-1. NTO distance to planning target volume (PTV), start dose, and end dose were 1 mm, 105%, and 60%, respectively, for all plans. In addition, planning without the NTO was arranged to find out its effect on planning. The prescription dose covered 95% of the PTV. Planning was evaluated using several indices: conformity index (CI), homogeneity index (HI), gradient index (GI), modified gradient index (mGI), comprehensive quality index (CQI), and monitor unit (MU). Differences among automatic NTO, manual NTO, and without NTO were evaluated using the Wilcoxon signed-rank test. Results: Comparisons obtained without and with manual NTO were: CI of 0.77 vs. 0.96 (p = 0.002), GI of 4.52 vs. 4.69 (p = 0.233), mGI of 4.93 vs. 3.95 (p = 0.001), HI of 1.10 vs. 1.10 (p = 0.330), and MU/cGy of 3.44 vs. 3.42 (p = 0.460). Planning without NTO produced a poor conformity index. Comparisons of automatic and manual NTOs were: CI of 0.92 vs. 0.96 (p = 0.035), GI of 5.25 vs. 4.69 (p = 0.253), mGI of 4.46 vs. 3.95 (p = 0.001), HI of 1.09 vs. 1.10 (p = 0.004), MU/cGy of 3.31 vs. 3.42 (p = 0.041). Conclusions: Based on these results, manual NTO with a priority of 100 and dose fall-off 0.5 mm-1 was optimal, as indicated by the high dose reduction in normal tissue.

Modelling the effects of lung cancer motion due to respiration

Adamczyk M., Adamczyk S., Piotrowski T.

Nukleonika

2018

Vol. 63, No. 4

95--103

Background and objectives: To justify the concept of validating conformal versus intensity-modulated approach in the treatment of non-small cell lung cancer (NSCLC). Materials and methods: For 10 patients representative of the spectrum of tumour sizes and locations, two plans were prepared: one with three-dimensional conformal radiation therapy (3DCRT) technique and the other with intensity-modulated radiation therapy (IMRT) technique. Preliminary measurements were performed in static conditions. For each of the field angles considered, the motion kernel was generated to simulate tumour motion trajectories, with the largest amplitude in the cranio-caudal direction of 4, 6, and 8 mm. The measurement results determined the agreement between the planned and measured doses. Results: No statistically significant differences were found between the motion patterns, with the smallest amplitudes for clinical target volume in 3DCRT. For IMRT, the significant differences between 0 mm vs. 6 mm and 0 mm vs. 8 mm amplitudes were found. The motion impact on delivered vs. planned doses had less effect on the oesophagus in 3DCRT compared to that in IMRT. The observed differences were comparable for the heart. Interpretation and conclusions: For maximal amplitudes below 4 mm, the disagreement between planned and delivered doses can be neglected. However, the amplitudes above 5 mm and 7 mm lead to significant changes in IMRT and 3DCRT dose distribution, respectively.