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Polymers in pharmaceutical taste masking applications

Amelian A., Winnicka K.

Polimery

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2017

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T. 62, nr 6

419--427

EN

Taste masking is an important factor in the development of dosage forms containing active pharmaceutical ingredients with unacceptable taste. Film coating has been found as the most effective and commonly used approach for taste masking. Depending on the taste masking technology, shell material should be selected from a wide variety of water soluble or insoluble polymers. The present article provides an overview of the commonly used polymers and ready-to-use polymer mixtures employed for taste masking.

PL

Maskowanie smaku jest ważnym czynnikiem w projektowaniu postaci leków zawierających substancje czynne o nieakceptowalnym smaku. Najskuteczniejszą i powszechnie stosowaną metodą maskowania smaku jest powlekanie opracowywanej postaci leku. Materiał otoczki stanowią rozpuszczalne lub nierozpuszczalne w wodzie polimery odpowiednio dobrane w zależności od metody maskowania smaku. W niniejszym artykule dokonano przeglądu polimerów oraz ich gotowych mieszanin, powszechnie używanych w celu zamaskowania smaku leku.

2

Antifungal Microcapsules of Ethyl Cellulose by Solvent Evaporation and Their Application to Cotton Fabric

Erkan G., Sarıışık M.

Fibres & Textiles in Eastern Europe

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2015

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Vol. 23, no. 6 (114)

125--130

EN

In this study two antifungal pharmaceutical agents, terbinafine and ketoconazole, were microencapsulated by solvent evaporation. Two types of ethyl cellulose with different viscosity values were used. Microcapsules were evaluated by X-ray diffractometry, DSC, FTIR and SEM analysis. Although the characteristic peaks of ketoconazole appeared in the X-ray diffractometry, those of terbinafine disappeared. The same results were observed for DSC analysis. The melting point of ketoconazole existed, while that of terbinafine was not observed. The microcapsules had a spherical shape, however the particle size varied between 5 and 120 μm. The microcapsules were applied to 100% cotton fabric. The washing of fabrics was performed in various washing cycles, and afterwards antifungal tests were performed. The fabrics had antifungal properties against Trichophyton rubrum, which causes mycoses, up to 5 washing cycles.

PL

Zastosowano dwa antygrzybiczne farmaceutyki, terbinafinę i ketokonazol, wprowadzano do mikrokapsułek uzyskanych przez odparowanie rozpuszczalnika. Zastosowano dwa typy etylocelulozy o różnej lepkości. Mikrokapsułki badano za pomocą dyfrakcji rentgenowskiej, DSC, FTIR i SEM. Podczas gdy charakterystyczne piki ketokonazolu były widoczne w badaniach rozproszenia rentgenowskiego, piki terbinafiny nie były widoczne. Te same wyniki zaobserwowano przy zastosowaniu analizy DSC, punkt topnienia ketokonazolu był widoczny podczas gdy punktu topnienia terbinafiny nie można było zaobserwować. Kształty mikrokapsułek były sferyczne o różnych rozmiarach od 5 do 120 µm. Mikrokapsułki zastosowano do impregnacji 100% tkanin bawełnianych. Tkaniny prano stosując różne cykle pralnicze, a następnie przeprowadzano testy antygrzybiczne obrabianych tkanin. Testy wykazały antygrzybiczne właściwości przeciwko Trichophyton rubrum, powodujących grzybice, nawet do pięciu cykli pralniczych.

3

Sustain release Formulation and Evaluation of Ofloxacin floating delivery system

Patel A. J., Naik D. R., Raval J. R.

International Letters of Chemistry, Physics and Astronomy

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2014

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Vol. 12

69--83

EN

Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug. The objective of present study outlines the development and characterization the floating drug delivery system of Ofloxacin to enhance its bioavailability and therapeutic efficacy, using different grades of polymer along with effervescent agent sodium bicarbonate and citric acid. Ofloxacin is a synthetic chemotherapeutic second-generation antibiotic of the fluoroquinolone class. Different tablet formulations were formulated by wet granulation technique and were evaluated for physical parameters like Tablet Thickness, Hardness, % Friability, Weight variation, Content uniformity, In vitro buoyancy, Swelling index, In vitro dissolution study and drug release mechanisms. As the concentration of the polymer in the formulations increased the release of drug decreased. Hence it was considered as suitable candidate for formulation as floating drug delivery system. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and kinetics. The optimized formula F4 showed better sustained drug release with good floating properties and fitted best to be Korsmeyer-Peppas model with R2 value of 0.9575. As the n value for the Korsmeyer- Peppas model was found be more than 0.5 it follows Non-Fickian diffusion mechanism. FTIR result showed that there is no drug excipients interaction.