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Bufadienolides - natural, biologically active compounds for medicines and cosmetics. A review.

Szymczak Kamil, Bonikowski Radosław

Biotechnology and Food Science

2023

Vol. 85, nr 1

3--15

Toad skin secretions are a rich source of various biologically active compounds, such as alkaloids, bufadienolides, biogenic amines, or peptides. Also plants from Hyacinthaceae and Crassulaceae can be a potent source of these groups of molecules. These compounds play a crucial role in amphibians’ and plants’ physiology such as defense against predators or pathogenic microorganisms. Among them, bufadienolides are the focus of many researches in recent years. These molecules have a very interesting, steroidal chemical structure and have potent activity at the cellular level. They possess cardiotonic, antiviral, antibacterial, antitumor, anti-inflammatory, hemostatic, bacteriostatic, wound-healing, and antiparasitic properties. Although the structures of about 500 bufadienolides are known, it is strongly suggested that this group of compounds is still very poorly examined. Moreover, bufadienolides may be an excellent basis for the chemical synthesis of new drugs with selective bioactivity. The aim of this paper is to briefly overview bufadienolides as potent compounds for medicines and cosmetics.

Owady jako remedia w polskim lecznictwie ludowym doby zaborów i II Rzeczypospolitej

Wdowiak L., Wysokiński P.

Kwartalnik Historii Nauki i Techniki

2018

R. 63, nr 1

89--118

Insects constitute as much as 75% of all described species of the world’s fauna. In the animal kingdom they play a dominant role. To certain extent it was reflected in folk medicine using zoonotic drugs. The purpose of the work is to determine, what kinds of insects were used t the time of Poland’s partitions and in the 2nd Polish Republic. Insects were used most often in such diseases, as: rheumatoid arthritis, paralysis, circulatory insufficiency and resulting oedemas, malaria, erysipelas, rabies, viper bites, trachoma, jaundice, skin diseases, cuts, hysteria. Close to 20 insect families were applied in folk medicine, although not all of the species can be counted, the more so as they were not always distinguished by the people of old Polish territories - both peasants and the researchers of their culture. Most often beetles and hymenopteras were used, less often - butterflies. There was widespread belief connected with this therapy, i.e. belief in magical meaning of numbers, especially number 3 and its multiple