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A fast chemometrics approach to quantitative analysis of metformin hydrochloride, enalapril maleate, and captopril in tablets based on HPLC-PAD spectra

Muhire Jules, Li Bao Qiong, Zhai Hong Lin, Wang Xue, Xu Min Li

Acta Chromatographica

2019

Vol. 31, no. 3

228--234

Diabetes mellitus and concurrent hypertension disorder are dreadful all over the world and are often managed by some drugs, such as metformin hydrochloride (MFH), enalapril maleate (ENM), and captopril (CAP). In this work, a reliable and fast quantitative analysis of these three components in tablets was carried out by Tchebichef image moment method and multivariate curve resolution with alternating least squares on three-dimensional (3D) spectra obtained by high-performance liquid chromatography coupled with photodiode array detection (HPLC-PAD). 3D spectra were obtained within only 2 min, and linear quantitative models were established by stepwise regression based on the calculated image moments. Among these two methods, Tchebichef image moment method showed outcome distinction. The correlation coefficients of cross-validation (RLoo-cv) are more than 0.988, while their recoveries are 100.1 ± 1.7% (MFH), 95.4 ± 5.4% (ENM), and 105.3 ± 5.7% (CAP), respectively. The intra- and inter-day precisions (RSD) are less than 5.42%. The proposed methods were also applied to the analysis of real tablets. This study reveals the effectiveness and convenience of the proposed image-moment method that may be a potential technology for the quality control and investigation of drugs in routine analysis.

An RP-HPLC method for simultaneous analysis of, and interaction studies on, enalapril maleate and H 2 -receptor antagonists

Sultana N., Arayne M. S., Naveed S., Shamshad H

Acta Chromatographica

2009

Vol. 21, no. 4

547--558

A simple, sensitive, and rapid RP-HPLC method for analysis of enalapril in the presence of H 2 -receptor antagonists has been developed and validated. Enalapril maleate was separated from H 2 -receptor antagonists by use of a 250 mm × 4.6 mm, 5-µm particle, C 18 column with 86:14 ( υ / υ ) methanol-water, pH adjusted to 3.5, as mobile phase, at a flow rate of 1.5 mL min -1. UV detection was performed at 227 nm. The retention times of enalapril maleate, ranitidine, cimetidine, and famotidine were 3, 5, 7, and 7.5 min, respectively. The detection limit for enalapril was 10 ng mL -1 and the calibration plot was linear in the range 2.5–50 µg mL -1. In-vitro interaction of enalapril with the commonly administered H 2 -receptor antagonists cimetidine, ranitidine, and famotidine in simulated gastric juice at different pH and 37°C was also studied by use of this method. These studies clearly indicated that most of these H 2 -receptor antagonists bind to enalapril causing drastic changes in the availability of the drug. The HPLC method is accurate, selective, sensitive, and reproducible.