Wyniki wyszukiwania - BazTech

Ograniczanie wyników

Znaleziono wyników: 3

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: działanie cytotoksyczne

Sortuj według:

Ogranicz wyniki do:

A comparative study of thyme ( Thymus vulgaris L.) essential oils and thymol – differences in chemical composition and cytotoxicity

Fijałkowska Aurelia, Wesołowska Aneta, Rakoczy Rafał, Jedrzejczak-Silicka Magdalena

Chemical and Process Engineering : New Frontiers

2024

Vol. 45, nr 1

art. no. e55

The chemical composition of commercial thyme oils, freshly hydrodistilled EO (essetntial oil) from dried thyme herb and thymol, the main thyme oil constituent, were analyzed in the aspect of possible cytotoxic effect against MCF-7 breast cancer and normal L929 mouse fibroblast cell lines. Based on the GC-MS analysis, it was found that the commercial essential oils revealed similarities in their chemical composition. The content of main components such as thymol, linalool and α-pinene was almost equal. Interestingly, the EO obtained by hydrodistillation from Thymi herba showed considerable differences in the percentage content of some main constituents. The reason for the differences may be caused by the intraspecific chemical variability of T. vulgaris L. Four types of tested EOs can be classified as a ‘thymol’ chemotype, with thymol as the predominant compound. The thymol alone and the freshly hydrodistilled EO demonstrated the highest cytotoxic effect against used cell lines. The difference in IC50 values suggests more sensitive L929 cells are more sensitive in both the CCK-8 assay (except EOs Kawon) and the NRU assay.

Study on in vitro toxicity of biometal(II) Monensinates against rat Zajdela liver tumour

Alexandrova Radostina, Zhivkova Tanya, Ivanov Dimitar, Andonova-Lilova Boika, Dyakova Lora, Pantcheva Ivayla, Dorkov Peter

Chemistry-Didactics-Ecology-Metrology

2020

R. 25, NR 1-2

125--132

The ability of Monensic acid A (MonH∙H2O) and its neutral metal complexes [M(Mon)2(H2O)2]with ions of Mg2+, Ca2+, Mn2+, Co2+, Ni2+ and Zn2+ to decrease viability and proliferation of primary cell cultures, originating from a chemically induced transplantable liver tumour of Zajdela in rats, and bone marrow cells from the same tumour-bearers, was evaluated. Experimental data revealed that manganese(II) and nickel(II) complexes of Monensin A are relatively more selective against the tumour as compared to the healthy bone marrow cells.

Badania działania cytotoksycznego membran chitozanowych przeznaczonych na opatrunki

Modrzejewska Z., Paluch D.

Engineering of Biomaterials

2011

Vol. 14, no. 103

23--28

W pracy przedstawiono badania dotyczące cytotoksycznego działania hydrożelowych membran chitozanowych wytwarzanych metodą inwersji faz. Hydrożelowe membrany stanowić mogą potencjalny materiał na opatrunki. Badania przeprowadzono na referencyjnej linii komórkowej, fibroblastach mysich 3T3/Balb. Membrany chitozanowe po 24, 48 i 72 h kontaktu, nie wykazują działania toksycznego. Plastyfikacja membran w glicerynie wpływa niekorzystnie przeżywalność komórek.

Investigations of cytotoxic activity of chitosan hydrogel membranes produced by the phase inversion method are presented in the paper. Hydrogel membranes can be used potentially as a dressing material. Experiments were carried out on a reference cell line, mouse fibroblasts Balb/C 3T3. Chitosan membranes after 24, 48 and 72 h exposure did not reveal any toxic activity. Plastification of the membranes in glycerin had a negative effect on cell survival.