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Polymeric drug carriers—Control of the daily dose and therapy duration

Trusek-Holownia A., Jaworska P.

Biocybernetics and Biomedical Engineering

2015

Vol. 35, no. 3

192--197

This study evaluates the mass release of cyanocobalamin with various drug carriers. Monolithic structures with a liquid core covering a thick (>150 μm) porous, polymer membrane are recommended. Membrane pore size should ensure easy diffusion of the drug molecules. The selection of the carrier's parameters to fit a required daily dose and therapy duration must consider the following criteria: 1′ the determination of its size (geometric surface); 2′ the number of carriers, if more than one is necessary; 3′ the thickness of membrane covering the carrier; and 4′ the mass of the loading drug. An algorithm to select these conjugated parameters to achieve the therapeutic threshold and duration of the drug effect was expanded upon. A system to constantly deliver drugs over days/weeks/months can be maintained if the loaded mass of the drug significantly exceeds its solubility in the carrier's core.