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2 2022

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Multi-molecule imaging and inter-molecular imaging in nuclear medicine

Shimazoe Kenji, Uenomachi Mizuki

Bio-Algorithms and Med-Systems

2022

Vol. 18, no. 1

127--134

Multi-molecule imaging and inter-molecular imaging are not fully implemented yet, however, can become an alternative in nuclear medicine. In this review article, we present arguments demonstrating that the advent of the Compton positron emission tomography (Compton-PET) system and the invention of the quantum chemical sensing method with double photon emission imaging (DPEI) provide realistic perspectives for visualizing inter-molecular and multi-molecule in nuclear medicine with MeV photon. In particular, the pH change of InCl3 solutions can be detected and visualized in a three-dimensional image by combining the hyperfine electric quadrupole interaction sensing and DPEI. Moreover, chemical states, such as chelating, can be detected through angular correlation sensing. We argue that multi-molecule and chemical sensing could be a realistic stream of research in future nuclear medicine.

A double photon coincidence detection method for medical gamma-ray imaging

Uenomachi Mizuki, Shimazoe Kenji, Takahashi Hiroyuki

Bio-Algorithms and Med-Systems

2022

Vol. 18, no. 1

120--126

Cascade nuclides emit two or more gamma rays successively through an intermediate state. The coincidence detection of cascade gamma rays provides several advantages in gamma-ray imaging. In this review article, three applications of the double photon coincidence method are reviewed. Double-photon emission imaging with mechanical collimators and Compton double-photon emission imaging can identify radioactive source positions with their angular-resolving detectors, and reduce the crosstalk between nuclides. In addition, a novel method of coincidence Compton imaging is proposed by taking coincidence detection between a Compton event and a photopeak events. Although this type of coincidence Compton imaging cannot specify the location, it can be useful in multinuclide Compton imaging.