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1 Polish Journal of Applied Chemistry

1 2005

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Preliminary optimization of direct amination of 1-(2,6-dimethylphenoxy)-2-propanol. synthesis of 1-(2,6-dimethylphenoxy)-2-aminopropane

Leś A., Kajl M., Szelejewski W.

Polish Journal of Applied Chemistry

2005

Vol. 49, nr 3

195-203

Preliminary steps were reported of optimization of catalytic amination of 1-(2,6-dimethylophenoxy)-2-propanol in our new synthesis of 1-(2,6-dimethylphenoxy)-2-aminopropane (mexiletine). In our search for optimal conditions a series of experiments were performed based on the concept of fractional factorial design. A detailed statistical analysis of reaction responses indicated necessary modifications of the synthesis. Elevated temperatures and the use of a more efficient catalyst were found necessary in order to use direct amination in industrial synthesis of pharmaceutically important amine from commercially available alcohol.