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1
Solid-State Spectroscopic and Structural Elucidation of L-Phenylalanyl-L-alanine Dihydrate and Its Hydrochloride
Zareva S., Kolev T., Tchapkanov A., Spiteller M., Koleva B.
Polish Journal of Chemistry
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2009
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Vol. 83, nr 3
421-430
EN
Correlation structure/IR-spectroscopic properties of the dipeptide L-phenylalanyl-Lalanine dihydrate (H-Phe-Ala-OHź2H2O) and its hydrochloride (H-Phe-Ala-OHźHCl) in solid-state is elucidated by means of the linear-polarized IR- (IR-LD) spectroscopy of oriented colloid suspension in nematic host. The IR-spectroscopic and structural assignment obtained by the polarization tool is compared with known crystallographic data of H-Phe-Ala-OHź2H2O. The characterization of the hydrochloride salt is supported in addition by the HPLC tandem ESI mass spectrometry (MS/MS), 1H- and 13C-NMR, TGA and DSC methods. Quantum chemical calculations are performed with a view to obtain electronic structure and vibrational properties of both neutral and protonated dipeptide, thus completing the experimental assignment.
2
Bis(2-amidophenyl) Diselenides Derived from Amino Acids and Dipeptides: Synthesis, Antiviral and Antimicrobial Activity
Palus J., Dąbrowska E., Piętka-Ottlik M., Piasecki E., Młochowski J.
Polish Journal of Chemistry
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2008
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Vol. 82, nr 5
1015-1022
EN
Synthesis of bis(2-aminophenyl) diselenide 1 derivatives, having amino acids and dipeptides moieties, has been reported. This process has been realized by acylation of both amine groups in 1 us ing N-Boc blocked amino acids 8 in the presence of DCC and HOBT, followed by deprotection to hydrochlorides 9. The free amines 2 have been obtained by removing the protective groups. In the similar way dipeptides 3, 10 and 11 have been prepared. Selected compounds have been tested as potential antiviral, antibacterial and antifungial agents.
3
Content available remote Kinetic analysis of transport and hydrolysis of dipeptides, a new osmotic agent for peritoneal dialysis solution
Weryński A., Waniewski J., Wang T., Anderstam B., Lindholm B., Bergström J.
Biocybernetics and Biomedical Engineering
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2007
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Vol. 27, no. 1-2
71-82
EN
A mixture of dipeptides (DP) have been proposed as an alternative (to glucose and amino acids, AA) osmotic agent in peritoneal dialysis (PD) solutions. The following solutions were used: (1) the amino acids (AA) solution containing leucine, valine, lysine, isoleucine, threonine, phenylalanine and histidine (tyrosine was omitted because of its poor solubility), (2) the dipeptide (DP) solution containing leucyl-valine, lysyl-isoleucine, threonyl-phenylalanine and histidyl-tyrosine. Sixteen Sprague-Dawley rats were used in the experiments. Kinetic models were developed for estimation of the diffusive mass transport coefficient between the peritoneal cavity and blood (KBD), the DP hydrolysis rate coefficient (KH ) and the AA clearance in the body (KC). The calculations show that KH is about ten times smaller than KBD. Thus, the hydrolysis rate in the peritoneal cavity is much smaller than the diffusive transport rate of DP. KBD for AA appeared to be similar to KBD for dipeptides. KC was much higher than KBD for AA. This finding explains the rapid clearance of amino acids from blood. The peritoneal transport characteristics of AA and DP were similar; however, their kinetics in blood considerably differed. The DP solution resulted in a less pronounced increase of the AA concentrations in blood, suggesting that the DP solution could provide the AA supply/delivery in a more physiological way.
4
Kinetic Studies of Nitric Oxide Uptake in Co(II)-Dipeptide-NO-OH- Systems by the Stopped-Flow Method
Kufelnicki A., Jaciubek-Rosińska J.
Polish Journal of Chemistry
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2006
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Vol. 80, nr 5
783-790
EN
The known up to now reactions of NO uptake by cobalt(II) chelates with selected dipeptides, observed previously by classic volumetric and pH-metric measurements, were now investigated kinetically by using the rapid kinetics stopped-flow method. The kinetic results could have been correlated with the reversibility of nitrosylation (estimated spectrophotometrically in the near IR after re-argonation).
5
Reversible Uptake of Nitric Oxide in Co(II)-Dipeptide-NO-OH- Systems
Kufelnicki A., Jaciubek J.
Polish Journal of Chemistry
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2001
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Vol. 75, nr 12
1905-1911
EN
Uptake of nitric oxide by cobalt(II) chelates with selected dipeptides was iiwestigated by volumetric and spectrophotometric methods (UV, VIS). The temperaturę was reduced to ~0°C in order to inhibit the autooxidation of Co(II) to Co(III). The stoichiometry of NO addition and the reversibility of the reaction (by re-acidification and re-argonation) were investigated as well. The reaction was reversible in a varying degree depending on the kind of amino acid side groups used. The kinetic stability of the formed NO adducts was followed spectrophotometrically. Present and previous results, concerning fixation of dioxygen in similar systems, arę compared.
6
Zastosowanie rozpuszczalników organicznych w reakcjach enzymatycznych z reagentami trudnorozpuszczalnymi w wodzie
Trusek-Hołownia A., Noworyta A.
Zeszyty Naukowe. Inżynieria Chemiczna i Procesowa / Politechnika Łódzka
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1999
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Z. 26
179-184
PL
Przy udziale termolizyny [EC 2.4.24.4] przeprowadzono reakcję syntezy prekursora gorzkiego dipeptydu ZAlaPheOMe. W zastosowanym układzie dwufazowym octan etylu - woda uzyskano równowagowe przereagowanie substratu bliskie jedności. Jako interesujące rozwiązanie procesowe przedstawiono kontaktorowy reaktor membranowy ułatwiający separację faz i stwarzający możliwość wielokrotnego wykorzystania fazy wodnej.
EN
The synthesis of ZAlaPheOMe using thermolysin in water, methanol-water solution and in binary system ethyl acetate-water was carried out. It was shown the synthesis in binary system was the most effective. The membrane contactor as an interesting solution for continuous reaction in this system was proposed.
7
Zastosowanie proteazy z dyni figolistnej Cucurbita ficifolia w syntezie gorzkich dipeptydów
Trusek-Hołownia A., Noworyta A.
Zeszyty Naukowe. Inżynieria Chemiczna i Procesowa / Politechnika Łódzka
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1999
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Z. 26
173-178
PL
Prezentowana praca dotyczy wykorzystania proteazy z soku dyni figolistnej Cucurbita ficifotta w reakcji syntezy dipeptydów, prekursorów gorzkich substancji. Podjęto próbę syntezy dwóch wybranych związków - ZLeuPheNH2 i ZPhePheNH2. W celu dobrania odpowiedniego środowiska reakcji przebadano 17 rozpuszczalników organicznych, zarówno hydrofobowych jak i hydrofilowych. Znaczący efekt reakcji uzyskano w roztworze butanolu zawierającym 2-8% wody.
EN
Dipeptides synthesis using protease from Cucurbita ficifolia was carried out ZLeuPheNH2 and ZPhePheNH2, the precursors of bitter dipeptides, were synthesised. Seventeen organic solvents (hydrophobic and hydrophilic) for the purpose of the reaction system selection was tested. Good results were obtained in butanol solutions contained 2-8%v/v of water.
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