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Therapeutic implications of computer models of brain activity for Alzheimer disease

Duch W.

Journal of Medical Informatics & Technologies

2000

Vol. 1

IP 27--34

Neural models of large-scale brain processes help to explain many features of neuropsychological syndromes and psychiatric disease. Two associative memory models useful to understand some aspects of cognitive impairments in Alzheimer disease are discussed. The first model is based on the synaptic deletion and compensation while the second on the synaptic runaway phenomenon. The models seem to be complementary, explaining different types of Alzheimer disease. They allow to draw several therapeutic suggestions that may help to slow down the development of the disease in its early stages.