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Computer aided diagnosis of diabetic macular edema in retinal fundus and OCT images: A review

Pavithra K.C., Kumar Preetham, Geetha M., Bhandary Sulatha V.

Biocybernetics and Biomedical Engineering

2023

Vol. 43, no. 1

157--188

Diabetic Macular Edema (DME) is a potentially blinding consequence of Diabetic Retinopathy (DR) as well as the leading cause of vision loss in diabetics. DME is characterized by a buildup of extracellular fluid inside the macula through hyperpermeable vessels. The presence of DME can be spotted at any level of DR with varying degrees of severity using prominent imaging modalities such as Color Fundus Photography (CFP) and Optical Coherence Tomography (OCT). Computerized approaches for screening eye disorders appear to be beneficial, as they provide doctors with detailed insights into abnormalities. Such a system for the evaluation of retinal images can function as a stand-alone disease monitoring system. This review reports the state-of-art automated DME detection methods with traditional Machine Learning (ML) and Deep Learning (DL) techniques employing retinal fundus or OCT images. The paper provides a list of public retinal OCT and fundus imaging datasets for DME detection. In addition, the paper describes the dynamics of advancements in presented methods adopted in the past along with their strengths and limitations to highlight the insufficiencies that could be addressed in future investigations.

Optical coherence tomography image for automatic classification of diabetic macular edema

Wang Ping, Li Jia-Li, Ding Hao

Optica Applicata

2020

Vol. 50, nr 4

567--577

Diabetic macular edema (DME) is the dominant reason of diabetic visual loss, so early detection and treatment of DME is of great significance for the treatment of diabetes. Based on transfer learning, an automatic classification method is proposed to distinguish DME images from normal images in optical coherence tomography (OCT) retinal fundus images. Features of the DME are automatically identified and extracted by the pre-trained convolutional neural network (CNN), which only involves fine-tuning the VGGNet-16 network without any user intervention. An accuracy of 97.9% and a sensitivity of 98.0% are acquired with the OCT images in the Duke data set from experimental results. The proposed method, a core part of an automated diagnosis system of the DME, revealed the ability of fine-tuning models to train non-medical images, allowing them can be classified with limited training data. Moreover, it can be developed to assist early diagnosis of the disease, effectively delaying (or avoiding) the progression of the disease, consequently.