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A new brain dedicated PET scanner with 4D detector information

Gonzalez-Montoro Andrea, Barbera Julio, Sanchez David, Mondejar Alvaro, Freire Marta, Diaz Karel, Lucero Alejandro, Jimenez-Serrano Santiago, Alamo Jorge, Morera-Ballester Constantino, Barrio John, Cucarella Neus, Ilisie Victor, Moliner Laura, Valladares Celia, Gonzalez Antonio J., Prior John, Benlloch Jose M.

Bio-Algorithms and Med-Systems

2022

Vol. 18, no. 1

107--119

In this article, we present the geometrical design and preliminary results of a high sensitivity organspecific Positron Emission Tomography (PET) system dedicated to the study of the human brain. The system, called 4D-PET, will allow accurate imaging of brain studies due to its expected high sensitivity, high 3D spatial resolution and, by including precise photon time of flight (TOF) information, a boosted signal-to-noise ratio (SNR). The 4D-PET system incorporates an innovative detector design based on crystal slabs (semi-monolithic) that enables accurate 3D photon impact positioning (including photon Depth of Interaction (DOI) measurement), while providing a precise determination of the photon arrival time to the detector. The detector includes a novel readout system that reduces the number of detector signals in a ratio of 4:1 thus, alleviating complexity and cost. The analog output signals are fed to the TOFPET2 ASIC (PETsys) for scalability purposes. The present manuscript reports the evaluation of the 4D-PET detector, achieving best values 3D resolution values of < 1,6 mm (pixelated axis), 2.7±0.5 mm (monolithic axis) and 3.4±1.1 (DOI axis) mm; 359 ± 7 ps coincidence time resolution (CTR); 10.2±1.5 % energy resolution; and sensitivity of 16.2% at the center of the scanner (simulated). Moreover, a comprehensive description of the 4D-PET architecture (that includes 320 detectors), some pictures of its mechanical assembly, and simulations on the expected image quality are provided.

Depth of interaction determination with temperature gradient function in continuous bismuth germanate oxide (BGO) crystal

Wolszczak W.

Bio-Algorithms and Med-Systems

2014

Vol. 10, no. 2

65--70

A method for depth of interaction (DOI) estimation with temperature gradient was considered. Preliminary results covered measurements of bismuth germanate oxide (BGO) monolithic crystal light pulse dependence on temperature. The proof of concept for using temperature gradient as a way to encode DOI incident γ in monolithic BGO crystal was presented.