In the present paper, the problem of estimating the contingent cone to the solution set associated with certain set-valued inclusions is addressed by variational analysis methods and tools. As a main result, inner (resp. outer) approximations, which are expressed in terms of outer (resp. inner) prederivatives of the set-valued term appearing in the inclusion problem, are provided. For the analysis of inner approximations, the evidence arises that the metric increase property for set-valued mappings turns out to play a crucial role. Some of the results obtained in this context are then exploited for formulating necessary optimality conditions for constrained problems, whose feasible region is defined by a set-valued inclusion.
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