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1 Polish Journal of Chemistry

1 2005

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Analogues of Arginine Vasopressin (AVP) Modified in the N-terminal Part of the Molecule with Stereoisomers of 4-Aminopyroglutamic Acid

Sobolewski D., Kowalczyk W., Derdowska I., Slaninova J., Kaczmarek K., Zabrocki J., Lammek B.

Polish Journal of Chemistry

2005

Vol. 79 / nr 4

731-737

The present work is a part of our studies aimed at clarifying the influence of sterical constraints in N-terminal part of AVP analogues on the pharmacological activity of the resulting peptides. In this study we described the synthesis of four new analogues of AVP substituted at positions 2 and 3 or 3 and 4 with two diastereoisomers of 4-aminopyroglutamic acid and four peptides in which we combined the above modification with the placement of 3-mercaptopropionic acid at position 1. All new peptides were not active in bioassays for pressor, antidiuretic and uterotonic activity.