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A Circuit Simplification Mechanism Based on DNA Combinatorial Strands Displacement

Niu Ying, Han Feng, Zhang Xuncai, Zhou Zheng

Fundamenta Informaticae

2019

Vol. 164, nr 2-3

243--257

DNA strand displacement technology has been widely used in the field of molecular computing. In the traditional strand displacement circuits, the DNA strands of the toehold domain and the branch migration domain are connected by covalent bonds, while the toehold domain and the branch migration domain of the combinatorial strand displacement are located in different single-stranded DNA (ssDNA), and the flexible combinations of the two domains are realized by the hybridization of the linking domains. It has obvious advantages in the design of multi-input circuits. In this paper, the AND gate, OR gate and XOR gate are constructed by the combinatorial strand displacement mechanism. On this basis, the half-adder and encoder circuit are constructed. The Visual DSD simulation results show that when the DNA molecular signal strands are input, the desired DNA molecular signal strands are output by the specific intermolecular hybridization reaction and the intermolecular strand displacement reaction, which proves the validity and feasibility of the logic circuit.