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Comparative physiological aspects of plasma hemostasis of some commercial fish species

Alobaidy Holya, Saleem Hayder Dawood, Al-Dhalimy Aiman Mohammed Baqir

Journal of Water and Land Development

2022

no. 54

239--242

The hemostasis system is designed to ensure the integrity of the body’s internal environment, stop bleeding, and maintain a liquid state of blood in the vascular channel. Modern biological and veterinary science presents highly fragmented and scarce data containing clinical and diagnostic clotting characteristics in different fish species. An essential point emphasising the practical component of such studies is spontaneous thrombus formation in fish farming described in the literature. The present research is devoted to the study of the functional state of plasma hemostasis in some ray-finned commercial fishes: phylogenetically more ancient cartilaginous ganoids - sturgeon Acipenser baerii and hybrid of sterlet A. ruthenus and starred sturgeon A. stellatus, as well as bony fishes - carp Cyprinus carpio and tilapia Oreochromis niloticus. It should be noted that the current study was performed at the aquaculture development center “AquaBioCenter” of VSDFA from 2015 to 2020. Species-specific features of clotting were revealed: activation by common and extrinsic pathways, characterised by thrombin time (TT), prothrombin time (PT), and fibrinogen concentration, is several times faster in cartilaginous ganoids than in both bony fish species; hemostasis with activation of the intrinsic pathway, characterised by activated partial thromboplastin time (APTT), is faster in hybrids and tilapias, in contrast to carps and sturgeons. Content of soluble fibrin monomer complexes (SFMC) in all fish was higher than in dogs and humans but lower than in cattle. The highest amount of SFMC was detected in carps, the lowest - in cartilaginous ganoids.

Multiscale approach to modelling blood flow

Jakubowicz A., Pietrzyk M.

Computer Methods in Materials Science

2013

Vol. 13, No. 4

480--492

The three dimensional multiscale model is introduced for studying of a clot formation in vessel with stenosis. The novel multiscale model based on separation of fluid flow calculation and red blood cells deformation is proposed. The macroscale model for fluid dynamic is described by lattice Bolzmann method (LBM). The deformation of red blood cells is defined by spectrin link method. The interaction between those two methods is handled by immersed boundary method. Simulation results demonstrate the structure of the thrombus for three simple geometries.

W artykule przedstawiony jest trójwymiarowy wieloskalowy model mający na celu modelowanie tworzenia się skrzepu w naczyniu krwionośnym ze zwężeniem. Zaproponowane nowatorskie podejście, oparte jest na rozdzieleniu obliczeń przepływu płynu i odkształceń krwinek czerwonych. Poziom makro przepływu krwi jest obliczony za pomocą metody siatkowej Boltzmann (ang. lattice Boltzmann method). Deformacja krwinek czerwonych opisana jest przez metodę powiązań spektryny (ang. spectrin link method).Interakcje między tymi dwoma metodami są możliwe dzięki metodzie zanurzonej ścianki (ang. immersed boundary method). Wyniki symulacji przedstawiają kształt skrzepu dla trzech prostych geometrii.