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2 Biocybernetics and Biomedical Engineering

2 2012

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Sporadic amyotrophic lateral sclerosis: brief pathogenic review and a new causal hypothesis

Sica R. E. P.

Biocybernetics and Biomedical Engineering

2012

Vol. 32, no. 4

17-32

This article summarizes the pathogenic mechanisms known to be responsible for sporadic amyotrophic lateral sclerosis, such as excitoxicity, endoplasmic reticulum stress, oxidative stress, proteins damage, inflammation, genes abnormalities and neuronal death; some clinical features of the disorder are discussed as well. Finally, it puts forward the hypothesis that astrocytes, rather than the motor neurons, may be the cells initially damaged by the action of a still unknown causal agent, being the neuronal death a consequence of that first insult. The article suggests that an emergent virus, perhaps a retro-virus, or a misfolded infectious protein might be the agent able to accomplish the task.

Continuous monitoring of feet temperature using a data logger with wireless communication

Foltyński P., Ładyżyński P., Wójcicki J. M., Brandl M., Grabner J., Migalska-Musiał K., Molik M., Sabalińska S., Ciechanowska A.

Biocybernetics and Biomedical Engineering

2012

Vol. 32, no. 4

59-64

The aim of the present study was to verify a system for continuous monitoring of feet temperature. The temperature measurement system developed in cooperation of the Center for Biomedical Technology (Krems, Austria) and Digilog Inc. (Perg, Austria) company was used for monitoring of the skin temperature on foot. The temperature monitoring devices are wirelessly controlled and they could be encapsulated in order to achieve waterproofing and facilitate disinfection with liquid disinfectant. The skin temperature measurements were performed every 1 or 5 minutes. Two healthy subjects were monitored for 7-9 days. The preliminary system application showed its usefulness in continuous temperature monitoring of feet.