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1 Journal of Medical Informatics & Technologies

1 2003

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The analysis of chromatin condensation state and transcriptional activity using DNA microarrays

Widłak P., Fujarewicz K.

Journal of Medical Informatics & Technologies

2003

Vol. 6

IP13--19

The DNA microarray-based technique has been developed to semi-quantitatively measure the in vivo global chromatin condensation state at the resolution of a gene. Chromatin was fractionated due to the differential solubility of histone H1-containing and histone H1-free nucleosomes. A set of genes non-randomly distributed between histone H1-free (uncondensed or open) and histone H1-containing (condensed or closed) chromatin fractions has been identified. The transcript levels have been measured for the same group of genes. The correlation between transcriptional activity and chromatin fraction distribution of particular genes has been established.