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1 Materials Science Poland

1 2005

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Spectroscopic properties of a chlorophyll-based photosensitive dye entrapped in sol-gel fibre-optic applicators

Ulatowska-Jarża A., Bindig U., Podbielska H., Hołowacz I., Stręk W., Müller G., Eichler H. J.

Materials Science Poland

2005

Vol. 23, No. 1

111--122

One of the promising modalities of modern medical treatment is interstitial laser therapy, where a special fibre-optic applicator is used to ensure a proper curing light distribution in the pathological lesion. Such an applicator can act as a light diffuser, and simultaneously it can serve as a carrier of the therapeutic medium, e.g. a photosensitive dye for photodynamic therapy in situ. For applicator construction, silica based sol-gels coatings are proposed in this paper. The sol-gel applicators were prepared from the silicate precursor TEOS (tetraethylorthosilicate) mixed with ethyl alcohol in acid-catalysed hydrolysis. A suitable amount of surfactant (Triton X-100) was used. The carrier matrices were produced with a solvent to precursor molar ratio of 20. In these studies, optical fibres from Laser Components were used (core diameter 400 nm, HCS, low OH). The external jacket was mechanically removed at a distance of 25 mm. The modified dip-coating method was exploited to cover the bare fibres with sol-gel material. Two types of applicators were produced, silica sol-gels with an addition of chlorophyll-derived sensibilisator (Photolon) in two various concentrations. It was proved that the immobilization of Photolon in a silica sol-gel does not destroy its chemical activity and does not disturb contact with the external environment.