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1 Acta Chromatographica

1 2008

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Separation of fudosteine on an achiral C 18 column by HPLC with chiral ligand-exchange selectors as mobile phase additives

Ma J., Cao J., Ding M. J., Yuan L. H., Zhai M. J., Zhang J., Zhang Q., Li F., Zhou X. M.

Acta Chromatographica

2008

Vol. 20, no. 4

585-594

A reversed-phase chiral liquid chromatographic method had been developed and validated for resolution of the enantiomers of racemic fudosteine. The effects on the separation of the amounts of anhydrous cupric sulfate and L -phenylalanine, the methanol content, mobile phase pH, and temperature were investigated. The method was validated for linearity, repeatability, intermediate precision, sample recovery, solution stability, and limits of detection (LOD). L -Phenylalanine and anhydrous cupric sulfate as chiral ligand-exchange complexes were used for separation, isomer identification, related substance investigation, and analysis of fudosteine enantiomers in fudosteine bulk drugs and fudosteine tablets.