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1 2012

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Evaluation of cytocompatibility of PLGA and PGLA-based nanocomposite biomaterials in osteoblast cultures

Ścisłowska-Czarnecka A., Stodolak-Zych E., Prawdzik E., Boguń M., Menaszek E.

Engineering of Biomaterials

2012

Vol. 15, no. 112

2-5

The aim of this study was to evaluate biocompatibility of multilevel composites based on bioresorbable poly(lactide-co-glycolide) (PGLA). Polymer matrix was modified with multidimensional (MD) short biopolymer fibers of calcium alginate (CA) containing bioactive ceramic nanoparticles (nanohydroxyapatite - HA or nanosilica - SiO2). The nanocomposite fibres present in the polymer samples influenced cells morphology, viability and secretory activity which was estimated using human osteoblasts cells (NHOst). The results indicate that biodegradable nanocomposite CA-HA/PGLA improves biological properties of the basic biomaterial (PGLA) suggesting its potential application for bone tissue engineering.