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Kropki kwantowe jako narzędzia diagnostyczne

Gruba Natalia, Rejmak Wiktoria, Romanowska Anita, Lesner Adam

Wiadomości Chemiczne

2024

[Z] 78, 3-4

369--387

The discovery of quantum dots (QDs) was a breakthrough event as it influenced almost every area of our lives. They are used in new technologies, the food industry, clothing production, and finally in medicine. Due to their unique properties, QDs are successfully used in the diagnosis of diseases of various origins - the so-called civilization diseases, infections and cancers. Quantum dots can also serve as tools to monitor the proteolytic activity of enzymes, effectively lowering the detection limit. Our team has been dealing with the proteolytic activity of enzymes for many years, especially in disease diagnosis, for which we also use quantum dots. In this article, we presented the main trends in the use of QDs as diagnostic tools.

Nieinwazyjne biomarkery do wykrywania raka pęcherza moczowego

Gruba Natalia

Wiadomości Chemiczne

2022

[Z] 76, 9-10

719--734

Bladder cancer (BC) is one of the most common cancer in the world. About 3% of all new cancer diagnoses are due to urinary bladder cancer. BC is also a leading cause of cancer-related death, as 2.1% of all cancer deaths are caused by bladder cancer. However, lack of a reliable biomarker is the biggest issue for BC diagnosis, prognosis and treatment. Development of non-invasive, quick and economical methods in bladder cancer diagnosis still remains a great challenge. Highly specific, easy-to-perform tests are really needed. Ideally if they can identify the presence of a tumor before the first symptoms appear, as time plays an important role in cancer. In this article, an overview of the current established diagnostic tests and newly identified biomarkers will be provided.

Monitorowanie aktywności proteolitycznej jako element diagnostyki chorób cywilizacyjnych

Gruba Natalia, Romanowska Anita, Rejmak Wiktoria, Sikora Honorata, Wysocka Magdalena, Lesner Adam

Wiadomości Chemiczne

2022

[Z] 76, 5-6

335--347

Proteolytic enzymes are essential for the proper functioning of every living cell. Due to their great importance in controlling metabolic changes in living organisms, they could be used in the diagnosis of civilization diseases. Hence, the search for new methods of determining and controlling their activity is extremely important. Our team, has been studying substrates of proteases and their potential use in detection of biomarkers activity for many years.