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Optical simulations and optimization of highly sensitive biosensor for cancer cell detection

El Mouncharih Abdelkarim, Takassa Rabi, Farkad Omar, Tchenka Abdelaziz, Ibnouelghazi El Alami, Abouelaoualim Driss

Optica Applicata

2023

Vol. 53, nr 3

407--418

In this work, using the two-dimensional finite difference time domain method, we are theoretically studying the optical properties of a two-dimensional photonic crystal biosensor based on silicon rods arranged as a square structure in an air bottom with two waveguides and a nanocavity. For this purpose, six different cells are infiltrated into the point defect. These six cells are Jurkat, HeLa, PC-12, MDA-MB-231, MCF-7, and basal cells. As a result, we have successfully detected cancer and benign cases of these cells through resonance peaks in the transmission spectrum. We evaluated the sensitivity, quality factor, detection limit, and figure of merit at different values for sensing region radius for optimization purposes. We report that we observed the maximum sensitivity of 1350 nm/RIU at 0.15 μm for the basal cell. Finally, the proposed biosensor can be a miniaturized structure with extreme sensitivity in cancer cell detection models.

The Cancer Cell Plasma Membrane Potentials As Energetic Equivalents to Astrophysical Properties

Persinger M. A., Lafrenie R. M.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 17, iss. 1

67--77

The primary physical and chemical parameters that define the hypopolarized plasma cell membrane of malignant (cancer) cells compared to non-malignant cells reflect universal characteristics. The median value for the resting membrane potential is the constant for the Nernst equation without reference to discrepancies in ion concentrations and is identical to Boltzmann energies at 37 °C. The threshold energy defining space-time converges with access to entropic processes that are reflected in the morphology of cancer cells and tumors. Slowing of growth in cancer cell lines but not normal cells following exposure to weak (~1 to 10 μT) patterned magnetic fields occurs when the energy induced within the cell corresponds to the energy equivalent of the hypopolarized membrane potential. The optimal temporal parameters for the efficacy of these fields can be derived from Hubble‟s parameter and the transform function for “noise” or “random” patterns within the system. Quantitative solutions and experimental data indicate that the cancer cell may be dominated by entropic process that can be attenuated or blocked by temporally-structured applied magnetic fields whose intensity matches the increment of energy associated with this threshold.