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Lipid microparticles as quercetin carriers for the treatment of burn wounds: manufacturing, properties, and in vitro studies on macrophages polarization

Stępień Julia, Kusibab Anna, Sousa Ana Beatriz, Barbosa Judite Novais, Pamuła Elżbieta

Engineering of Biomaterials

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2023

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vol. 26, no. 171

2--11

EN

Burn wounds are a unique type of injury that can affect the entire body and cause irreversible damage. They are characterized by significant morbidity and mortality due to the pathophysiology of the healing process manifested by unremitting inflammation, leading to a critical need to search for new treatments. This study focuses on the development of drug delivery systems in the form of lipid microparticles loaded with quercetin, as an agent to combat acute inflammation in burn wounds. We aimed to explore the effect of quercetin in modulating macrophage polarization from proinflammatory (M1) to anti-inflammatory (M2) phenotype. The absence of a cytotoxic effect of the produced particles on macrophages, as well as the lack of negative effects on their morphology was proven. The study confirmed the ability of quercetin and quercetin-loaded lipid microparticles to modulate macrophage polarization in an anti-inflammatory direction, based on the analysis of their surface markers expression performed with the use of flow cytometry. With the use of quercetin, the expression of M2 specific marker increased. Furthermore, better results were obtained for encapsulated quercetin, confirming the necessity of encapsulation to increase the therapeutic potential.

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Temperature field in burned and healthy tissue : sensitivity analysis with respect to the thermal parameters

Freus K., Freus S., Majchrzak E.

Journal of Applied Mathematics and Computational Mechanics

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2014

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Vol. 13, nr 3

47--58

EN

A non-homogeneous system being the composition of burn wound and healthy tissue is considered. The heat exchange between sub-domains and environment is described by the system of partial differential equations (the Pennes equations) supplemented by the assumed boundary conditions. Additional problems associated with sensitivity analysis with respect to thermal parameters occurring in the mathematical model are formulated. Both the basic problem and additional ones concerning the sensitivity with respect to selected parameters are solved using the boundary element method. In the final part of the paper the results of computations are shown.

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Planimetry of thermograms in diagnosis of burn wounds

Dziewoński M.

Prace Naukowe Instytutu Matematyki i Informatyki Politechniki Częstochowskiej

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2009

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Vol. 8, nr 1

33-38

EN

The article discusses the problems connected with thermography and presents the application used for the analysis of thermograms taken by a infrared camera. The application enables the reading of the temperature of a particular place chosen on the thermogram and the estimation of the area of the same temperature, in a specified area, established by the user. It is very helpful in the diagnosis of burn wounds, in the estimation of burnt surface area and in the analysis of the wounds healing.