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Bisbenzisoselenazol-3(2H)-ones, a New Group of Ebselen Analogues

Osajda M., Kloc K., Młochowski J., Piasecki E., Rybka K.

Polish Journal of Chemistry

2001

Vol. 75, nr 6

823-830

The title compounds with benzisoselenazolone moieties connected by spacers such as phenylene, bisphenylene, alkylene, oxaalkylene, azaalkylene and dithiaalkylene groups have been obtained in the reaction of 2-(chloroseleno)benzoyl chloride with compounds having two primary amine groups, while the secondary amines gave products of their selenenylation and/or acylation. Bisbenzisoselenazol-3(2H)-ones were found, in the antiviral assay in vitro, to be inhibitors of cytopathic activity of RNA and DNA viruses: EMCV, HSV-1 and VSV.