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1

Prospects for the production of radioisotopes and radiobioconjugates for theranostics

Choiński Jarosław, Łyczko Monika

Bio-Algorithms and Med-Systems

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2021

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Vol. 17, no. 4

241--257

EN

The development of diagnostic methods in medicine as well as the progress in the synthesis of biologically active compounds allows the use of selected radioisotopes for the simultaneous diagnosis and treatment of diseases, especially cancerous ones, in patients. This approach is called theranostic. This review article includes chemical and physical characterization of chosen theranostic radioisotopes and their compounds that are or could be useful in nuclear medicine.

2

Investigation of low temperature plasma capabilities to modify the structure and function of bio-polymers

Motrescu I., Hara T., Ogino A., Tanaka S., Fujiwara T., Kawagishi H., Kodani S., Popa G., Nagatsu M.

Journal of Automation Mobile Robotics and Intelligent Systems

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2009

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Vol. 3, No. 4

150-152

EN

The possibility to modify biopolymers using low temperature plasma is investigated. Two types of plasma are employed in this study: an atmospheric pressure plasma and a low pressure microwave plasma. In both cases changes of the structure and function of the exposed molecules are reported, the effects being stronger for the low-pressure plasma irradiation.

3

Zastosowanie spektroskopii jądrowego rezonansu magnetycznego w badaniach oddziaływań międzycząsteczkowych ligandów organicznych i biocząsteczek

Bocian W., Kozerski L.

Wiadomości Chemiczne

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2005

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[Z] 59, 1-2

3--22

EN

The title problem is reviewed in the three main areas of general interest to chemists, biochemists and biologists, i.e. mutual interactions of small molecules, ligand to biomolecule binding and interactions of biomolecules. Physical phenomena, specific and nonspecific, such as hydrogen bonding, self association, hydrophobic interactions, etc., are shown as being defined by NMR spectral parameters in solution and solid state. Diversity of hydrogen bonding encountered in nature is exemplified by the interaction of acetic acid with Watson-Crick vs Hoogsteen faces of adenosine, studied by DNMR in organic solvent at low temperatures. The complementarity of solid state NMR to solution studies of defining the nature of hydrogen bonding is presented in the case of genistein interaction with nitrogen bases. Application of a title method is presented for searching the geometry of complexes formed of organic ligands and biological molecules. General protocol for searching the geometry of complex is presented for the case of topotecan (TPT) interaction with duplex octamer and nicked decamer duplexes of DNA. Interaction of biomolecules is presented for the case of duplex octamer DNMR study showing effects of base pairing and stacking on the b 'H values and insulin aggregation as studied by Pulse Field Gradient NMR spectroscopy leading to relating the radius of molecular aggregate with the diffusion constants. In conclusion it is stated that various NMR techniques in solid and liquid state, coupled with X-ray and MS, constitute modern tool of structural biology in pursue of disclosing functions of biomolecules expressed by their interactions.

4

Możliwości wykorzystania promieniowania jonizującego w przemyśle spożywczym

Gralik J., Warchlewski J.R.

Przemysł Spożywczy

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1999

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T. 53, nr 10

31-34

PL

W konsekwencji napromieniowania materiału biologicznego pojawiają się zmiany o charakterze bezpośrednim i pośrednim. Powstające m.in. liczne reaktywne produkty radiolizy wody mogą reagować ze wszystkimi rodzajami biocząsteczek, które są ważnymi składnikami pokarmowymi. Precyzyjne dobranie dawki w zależności od napromienianego produktu pozwala na takie ukierunkowanie zmian chemicznych, że ich efektem jest poprawa właściwości fizykochemicznych, biochemicznych i technologicznych. Liczne badania prowadzone do tej pory wykazały, że w żywności napromienionej dozwoloną dawką (do 10 kGy) nie występują żadne substancje toksyczne lub kancerogenne oraz, że stosowanie technik radiacyjnych przy zachowaniu obowiązujących zasad bezpieczeństwa nie stwarza zagrożenia dla zdrowia ludzi.

EN

As a consequence of irradiation of biological material, direct and indirect changes appear. Extremely reactive molecules formed as a result of water radiolysis can react with all biomolecules which are essential food components. Doses, precisely chosen, with respect to the irradiated product allow to direct the chemical changes in order to obtain the physicochemical, biochemical and technological improvement. Many investigations proved so far that there were not any toxic or cancerous substances in food irradiated within legislated doses (up to 10 kGy) and that usage of irradiation technique is entirely sale for human health when safety regulations are met.