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Nickel comb capacitors for real-time monitoring of cancer cell cultures

Kociubiński Andrzej, Zarzeczny Dawid

Przegląd Elektrotechniczny

2020

R. 96, nr 9

149--152

The work is devoted to the technology of biocompatible substrates with nickel electrodes for in vitro impedance cell culture studies. The legitimacy of this subject was tested by conducting measurements using a system based on the Electric Cell-Substrate Impedance Sensor method. A device for cell bioimpedance testing, made in thin-film technology, has been described. Parameters and applications of the material used for construction, which is commonly used nickel, are discussed. The results of preliminary studies on melanoma cancer cells from the A375 cell line were presented, during which the already used measurement matrices were used. An analysis of the observed changes and obtained results was carried out.

Praca poświęcona jest technologii biokompatybilnych podłoży z niklowymi elektrodami do badań impedancji hodowli komórek in vitro. Zasadność podjęcia tej tematyki przetestowano przeprowadzając pomiary przy użyciu systemu opartego na metodzie ECIS (ang. Electric CellSubstrate Impedance Sensor). Opisano przyrząd służący do badań bioimpedancji komórek, wykonany w technologii cienkowarstwowej. Omówiono parametry i zastosowania wykorzystanego do budowy urządzania materiału, którym jest powszechnie stosowany nikiel. Przedstawiono wyniki wstępnych badań nad komórkami nowotworowymi czerniaka z linii komórkowej A 375, do których użyto wykonane matryce pomiarowe. Dokonano analizy zaobserwowanych zmian i otrzymanych rezultatów.

Possible interactions between stent and electromagnetic field

Barz C., Petters M., Dorsz A., Syrek P.

Science, Technology and Innovation

2018

Vol. 3, no. 2

48--51

Over the past years, an increase in the amount of the electromagnetic sources could be observed. Model presented in this article is limited to the impact of low frequency fields generated by the e.g. electrical power lines or magnetic coils in a bone fractures therapy. Particularly, the effect of the magnetic component of the electromagnetic field on stents will be evaluated. The conductivity of human tissues will be investigated. Yielded results will be used to simplify complicated, three-dimensional problem of the current distribution in stent branches, to one-dimensional one. The merits of the paper is proposing, implementing and using for analysis a numerical model of the stent in magnetic field. The impact of frequency and positioning of stent in the magnetic field will be investigated and current distributions found.

Mechanical properties variation and constitutive modelling of biomedical polymers after sterilization

Zanelli L., Todros S., Carniel E. L., Pavan P. G., Natali A. N.

Acta of Bioengineering and Biomechanics

2017

Vol. 19, no. 3

3--9

Purpose: In this work, the mechanical behavior of two block copolymers for biomedical applications is studied with particular regard to the effects induced by a steam sterilization treatment that biomedical devices usually undergo in healthcare facilities. This investigation is aimed at describing the elasto-plastic behavior of the stress-strain response, determining a functional dependence between material constitutive parameters, to obtain an optimal constitutive model. Methods: The mechanical properties of these polymers are analyzed through uniaxial tensile tests, before and after the sterilization process. The effect of sterilization on the mechanical behavior is evaluated. The Ramberg-Osgood model is used to describe the elasto-plastic behavior of the stress-strain response. Results: Data from uniaxial tensile tests are discussed in the light of previous data on the same polymeric materials, in order to highlight the correlation between physicochemical and mechanical properties variation. The material constitutive parameters are determined and the functional dependence between them is found, thus enabling an optimal constitutive model to be obtained. Conclusions: The effect of sterilization on the material constitutive parameters is studied, to evaluate the suitability of the model in describing the mechanical response of biomedical polymer before and after sterilization treatment. The same approach can be applied to other biomaterials, under various tensile tests, and for several processes that induce variation in mechanical properties.