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Biological evaluation of selective laser melted magnesium alloy powder

Pawlak Andrzej P., Szymczyk-Ziółkowska Patrycja E., Junka Adam, Chlebus Edward

Acta of Bioengineering and Biomechanics

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2021

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Vol. 23, no. 1

121--133

EN

Purpose: The current study examined magnesium alloy AZ31B specimens manufactured with Additive Manufacturing method (selective laser melting – SLM) to investigate the applicability of this technology for the production of medical devices. Methods: Osteoblast cells and bacterial biofilm growth ability on specimen was examined and the effect of surface state on corrosion resistance was evaluated by electrochemical and immersion methods. Results: High survival of hFOB cells, as well as a strong tendency for Pseudomonas aeruginosa and Staphylococcus aureus biofilm proliferation on the surface of the tested specimens were shown. SLM-processed AZ31B alloy has a higher corrosion resistance in 0.9% NaCl solution and in a multi-electrolyte saline solution than the material in a conventional form of a rolled sheet. Conclusions: It has been demonstrated that the strong development of the surface of as-built processed specimens results in a significantly increased corrosion rate, which hinders the production of complex structures in tissue engineering products that support cell ingrowth.

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Feasibility study of conformal forward planned simultaneous integrated boost technique comparable to IMRT and VMAT in pelvic irradiation for locally advanced cervical cancer

Johnjothi Sam Deva Kumar, Ranganathan Arulpandiyan, Jayapaul Vasanth Christopher, Santosham Rithesh, Rajasekaran Dhanabalan, Nagarajan Vivekanandan, Ganesharaja Selvaluxmy

Polish Journal of Medical Physics and Engineering

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2019

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Vol. 25, Iss. 2

111--119

EN

Aim: To check the feasibility of simultaneous integrated boost (SIB) using a forward planned field in field (FIF) conformal technique for the treatment of carcinoma of the cervix IIIB and compare it dosimetrically with other advanced inverse planning techniques. Methods: In our study 33 patients of carcinoma of the cervix IIIB were planned for SIB using conformal FIF technique and they were compared with retrospectively planned IMRT and VMAT techniques. SIB using conformal FIF was planned by two different methods. Results: The results of our study indicate that forward planned Conformal SIB techniques are comparable with inverse planned techniques dosimetrically, in terms of conformity Index, Homogeneity Index, Maximum dose, etc. The ability of FIF SIB plans to produce dose contrast in differential dose accumulation was compared and analyzed and the results were encouraging. To treat an advanced/bulky disease like Carcinoma of the Cervix IIIB in centers with large patient load, utilizing advanced techniques such as IMRT and VMAT is both technically and practically difficult. Despite VMAT’s shorter delivery time, the procedures involved are time-consuming. Conclusion: Hence forward planned SIB techniques may be used to achieve similar dosimetric effects of IMRT and VMAT techniques without much compromise in plan quality and patient throughput for treating bulky carcinoma of the cervix IIIB cases. However, the clinical results need to be carefully compared and evaluated and reported.

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Evaluation of the biocompatibility of a hydroxyapatite-CaTiO3 coating in vivo

Wu S., Tu B., Lin J., Wang Z., Wang X., Shen M., Hu R.

Biocybernetics and Biomedical Engineering

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2015

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Vol. 35, no. 4

296--303

EN

Objective: This study was designed to evaluate the biocompatibility and osteointegrative activity of hydroxyapatite (HA)-CaTiO3, titanium substrate, traditional HA coating and CaTiO3 coating via an animal experiment. Method: Four types of screws (type 1: coated with HA; type 2: coated with CaTiO3; type 3: coated with HA-CaTiO3; type 4: untreated titanium screws) were implanted into femur bone of 48 New Zealand rabbits. Histological and mechanical investigations were employed at the end of 2, 4, 8 and 12 weeks to evaluate the material osteointegration. Results: (1) All of the experimental rabbits were healthy during the experiment process. (2) Histological investigation showed fully regenerated and well integrated bone tissue surrounding the screws coated with HA, HA-CaTiO3 and CaTiO3. (3) Mechanical investigation showed that the bonding strength of HA-CaTiO3 coating was significantly higher than that of CaTiO3 coating or titanium materials without coating, but was lower than those coated with HA. Conclusion: HA-CaTiO3 coating possesses similar admirable biocompatibility and osteointegration activity with HA coating, indicating a promising coating material for implants in orthopedics.

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Assessment of Modified Knitted Hernia Implants after Implantation: I. Biological Effect on the Structural and Usable Properties

Kostanek K., Struszczyk M. H., Chrzanowski M., Żywicka B., Paluch D., Szadkowski M., Gutowska A., Krucińska I.

Fibres & Textiles in Eastern Europe

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2013

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Vol. 21, no. 6 (102)

79--83

EN

The purpose of this article is to discuss the solution of the main clinical adverse events occurring in less invasive reconstruction of hernia. The study attempted to design the knitted implants, contributing to reduce the risk of adhesion to the viscera. Specially designed knitting structure of the hernia implant allowed to introduce the one-side enhancement of the surface in the form of loops stitched-out of the surface accelerated the connective tissue in-growth. The opposite side was modified the treatment in low-temperature plasma of low molecular weight fluorogenic compound resulted in the deposition of fluoropolymer nano-layer. The effect of the modification on the adhesion of implant to viscera was studied in vivo. Additionally, the influence of the implantation time on the structural properties, the connective tissue covering implants single monofilaments as well as the stability of the fluoropolymer layer formed during the implantation were detailed investigated.

PL

Artykuł omawia techniczną próbę rozwiązania głównych problemów występujących w rekonstrukcjach przepukliny, wykonywanych techniką małoinwazyjną. W badaniach podjęto próbę zaprojektowania dzianego implantu, którego właściwości wpływają na zmniejszenie ryzyka jego adhezji do narządów wewnętrznych. Specjalnie opracowana struktura dziewiarska implantu do zaopatrywania przepuklin pozwoliła na uzyskanie jednostronnego rozwinięcia powierzchni w postaci wystających z powierzchni pętelek wspomagających proces wgajania tkanką łączną. Druga powierzchnia implantu została poddana modyfikacji w środowisku plazmy niskotemperaturowej niskocząsteczkowego związku fluoroorganicznego prowadząc do uformowania nanowarstwy fluoropolimeru. Umożliwiło to obniżenie ryzyka adhezji implantu dzianego do narządów wewnętrznych, co potwierdzono w badaniach in vivo. Prowadzono także ocenę wpływu czasu implantacji na właściwości strukturalne implantu, stopień pokrycia tkanką łączną pojedynczych monofilamentów oraz stabilność uformowanej nanowarstwy fluoropolimeru.

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Regulacje prawne i aspekty etyczne w badaniach doświadczalnych na zwierzętach

Solski L.

Inżynieria Biomateriałów

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2000

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R. 3, nr 12

8--11