Wyniki wyszukiwania - BazTech

1

Development and validation of a new RP-HPLC-UV method for the simultaneous determination of phenytoin impurities, benzophenone, and benzil

Sungthong Bunleu, Rattarom Ruchilak, Sato Vilasinee Hirunpanich, Sato Hitoshi

Acta Chromatographica

|

2019

|

Vol. 31, no. 4

241--245

EN

A new reversed-phase high-performance liquid chromatographic method with ultraviolet detection (RP-HPLC-UV) for simultaneous determination of phenytoin impurities, benzophenone and benzil, was developed and validated according to the International Council for Harmonization (ICH) guidelines. Chromatographic separation was performed on a C8 column using acetonitrile–1% acetic acid (60:40, v/v). The correlation coefficients of the calibration lines were greater than 0.999 with 95% confident interval of y-intercept over the origin. The analytical method showed good precision, intra-day precision ≤1.00 and inter-day precision ≤1.53. The standard solution of each compound exhibited good stability 99.18–99.70%, after storage at room temperature for 24 h. The limit of detection (LOD) and limit of quantification (LOQ) were 0.0015 and 0.005 μg/mL, respectively. The resolution of the impurities was 2.935 ± 0.009. The proposed analytical method was successfully applied to determine the amount of benzophenone and benzil in marketed products. The amount of benzophenone was found at 3.09–5.91 × 10−3%, while benzil was not detected in the samples.

2

Projekt SoLaPack – zapobieganie migracji substancji szkodliwych z opakowań pochodzenia celulozowego

Bal K., Kaszuba A.

Przegląd Papierniczy

|

2014

|

R. 70, nr 2

79--83

PL

Opakowania, oprócz podstawowej funkcji ochronnej, coraz częściej spełniają funkcję narzędzia informacyjnego, marketingowego i reklamowego. Jednym ze sposobów wyróżnienia opakowania jest jego wielobarwne zadrukowanie oraz lakierowanie zewnętrznej powierzchni. Papier i tektura nie stanowią wystarczającej bariery do zatrzymania migracji szkodliwych substancji i istnieje ryzyko zagrożenia bezpieczeństwa zdrowotnego znajdującego się w nich produktu spożywczego. Obecne w opakowaniach różne resztkowe środki pomocnicze, kleje, barwniki, rozjaśniacze optyczne oraz inne substancje uszlachetniające dodawane w procesie produkcyjnym, a także wprowadzane powierzchniowo z farb drukowych i lakierów mogą przedostawać się do żywności. Skutecznym sposobem zabezpieczenia produktów spożywczych może być zastosowanie odpowiednich warstw barierowych naniesionych na wewnętrzną stronę opakowania. Opracowanie warstwy sorpcyjnej pomiędzy opakowaniem a produktem spożywczym jest celem międzynarodowego projektu badawczego SoLaPack (Sorption Layers for Paperbased Packaging Materials), realizowanego w ramach inicjatywy CORNET przez jednostki naukowo-badawcze z Polski, Niemiec i Belgii. Powłoki barierowe wytwarzane są z różnorodnych substancji sorpcyjnych dopuszczonych do kontaktu z żywnością, takich jak: zeolity, cyklodekstryny, zmodyfikowane ziarna skrobi, glinokrzemianybetonity oraz mieszaniny krzemionki koloidalnej i wodorotlenku glinu. Jako substancje krytyczne wybrane zostały do badań cztery substancje szkodliwe dla zdrowia: benzofenon, bisfenol A, ftalany i oleje mineralne, mogące występować w opakowaniach celulozowych. Opakowania przeznaczone do kontaktu z żywnością wykazały bardzo zróżnicowaną zawartość substancji krytycznych (benzofenon, bisfenol A, ftalany i oleje mineralne), w niektórych przypadkach wynosiła ona kilkadziesiąt a nawet kilkaset mg/kg. Badania te potwierdziły celowość opracowania materiałów opakowaniowych z naniesioną warstwą sorpcyjną spełniającą rolę bariery ochronnej. Badania migracji specyficznej benzofenonu i bisfenolu A do Tenaxu® pozwoliły na wytypowanie materiałów z naniesionymi powłokami sorpcyjnymi o najlepszych własnościach barierowych. Stwierdzono, że wprowadzenie warstwy sorpcyjnej nie pogarsza właściwości fizyko-mechanicznych materiałów celulozowych.

EN

Packaging, in addition to basic protective function, serves increasingly as an information, marketing and advertising tool. This is achieved by a multi-colour printing of the packaging and coating the outer surface of the package. Paper and paperboard are not sufficient barriers to stop migration of harmful substances and therefore it is a risk to health safety for food product which is packed in. Contained in packaging, various residual additives, adhesives, dyes, optical brighteners and other materials added in the production process, as well as applied to the surface printing inks and coatings may cause them to migrate into food. An effective way of protecting food products can be use of suitable barrier layers applied to the inside of the packaging. Development of a sorption layer between packaging and food product is the goal of an international research project SoLaPack realized in the framework of the CORNET by research groups from Poland, Germany and Belgium. Barrier coatings are made of various sorptive substances approved for food contact such as zeolites, cyclodextrins, modified starch granules, aluminosilicates – bentonites and mixtures of colloidal silica and aluminum hydroxide. Four harmful substances were selected as critical for testing: benzophenone, bisphenol A, phthalates and mineral oils, which may be present in the cellulosic packaging. Packaging for food contact have demonstrated a very varied content of criticalsubstances (benzophenone, bisphenol A, phthalates and mineral oils), in some cases it was dozens or even hundreds of mg/kg. These studies have confirmed the desirability of the development of packaging materials coated with the adsorbent layer serving as a protective barrier. Research of specific migration of benzophenone and bisphenol A to Tenaxu ® allowed for predicting materials with the best barrier properties. It has been found that the introduction of the sorptive layers does not worsen the properties of physico-mechanical properties of cellulosic materials.

3

Interface interactions and optical properties of novel photonic nanocomposites consisting of porous glasses doped with organic luminophore molecules

Antropova T.V., Baran J., Gavrilko T., Gnatyuk I., Morawska-Kowal T., Melnik V., Puchkovska G., Vorobjev V.

Optica Applicata

|

2005

|

Vol. 35, nr 4

725-733

EN

Absorption and luminescence spectra of nanocomposites consisting of photonic molecules rhodamine 6G, trishydroxyquinoline aluminum (Alq3) complex and benzophenone adsorbed on soda-borosilicate porous glasses from ethanol and dichloromethane (DCM) solutions are investigated. The effect of sorption interactions at the interface between the glass pore surface and the organic media on luminescent and optical characteristics of the nanocomposites was investigated by NIR spectroscopy. It was shown that spectral changes observed in the absorption and emission spectra of the luminophores in the porous glasses are determined by the balance between physical interaction of the organic molecule with different adsorption centers on the pore walls and solvation effect.

4

Synthesis of New tetraoxacyclophanes Containing Benzophenone Units

Kuś P., Jones P.

Polish Journal of Chemistry

|

2000

|

Vol. 74, nr 7

965-977

EN

4,4'-Dihydroxybenzophenone was used as a precursor for synthesis of macrocyclic compounds.

5

Photoreduction of benzophenone by trithianes as the initiation step in radical polymerization

Andrzejewska E., Hug G., Andrzejewski M., Marciniak B.

Nukleonika

|

2000

|

Vol. 45, nr 1

83-91

EN

This work was presented at the Workshop on Reactive Intermediates in Sulfur Chemistry (Poznań, 1998). It is a summary of earlier investigations on the role of cyclic sulfides (1,3,5-trithiane derivatives) in accelerating the initiation of polymerization induced by benzophenone (BP). The primary photochemical reactions between BP and trithianes were followed by nanosecond laser flash photolysis. Tripletquenching rate constants and quantum yields for electrontransfer products and ketyl-radical formation were measured. Photoinduced polymerizations with model monomers initiated by BP/trithiane couples were followed by isothermal differential scanning calorimetry (DSC). The kinetics of these polymerizations were compared with the photochemical information on the quenching of excited BP by the trihianes. The polymerization efficiency using the various coinitiators did not follow the efficiency of photo-induced formation of the initiating radicals. The reasons for this lack of correlation were discussed in terms of the various factors that influence the polymerization aside from the efficiency of radical formation.