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2 International Letters of Chemistry, Physics and Astronomy

2 2014

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Synthesis, characterization and antimicrobial activity of 2-azetidinone derivatives of benzimidazoles

Mehta P., Davadra P., Pandya J. R., Joshi H. S.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 11, iss. 2

81-88

Some new 2-azetidinone derivatives possessing benzimidazole nucleus were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.

Synthesis and antimicrobial activity of some new imidazolinone derivatives containing benzimidazole

Mehta P., Davadra P., Shah N., Joshi H.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 10

74--80

In this study some new o-benzimidazol-2'-yl-benzamido-p'-benzamido-2-phenyl-4-substituted phenyl-5-oxo-Imidazolines 3a-3j were synthesized. To synthesized target molecules we used various substituted oxazolone derivatives, synthesized from substituted benzaldehyde with hippuric acid. Substituted oxazolones 2a-2j were reacted with carbohydrazide derivative of benzimidazole 1 in presence of pyridine as base to obtained substituted imidazolinone derivatives. All synthesized compounds were characterized by IR, 1H NMR, elemental analysis and further supported by mass spectroscopy. All synthesized compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria which showed moderate to good activity. All compounds showing good to moderate active against fungal strain as compare to standard drug.