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Novel Buspirone-Like 5-HT 1A Receptor Ligands

Krajewski K., Leś A., Cybulski J., Chilmonczyk Z., Bronowska A., Szelejewska-Woźniakowska A.

Polish Journal of Chemistry

2001

Vol. 75, nr 1

71-78

Four novel buspirone-like compounds were synthesized and their affinity to the serotonin 5-HT1A receptor was determined. Two compounds bind to 5-HT1A receptor with a high affinity and two other compounds exhibit a low affinity to this receptor. A simple two-parameter polynomial correlation was suggested to express the structure-activity relationships.