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Flow-injection chemiluminescence determination of aminoglycoside antibiotics using N-bromosuccinimide-fluorescein system

Fu Z., Zhang Z., Wang Z., Luo W., Fang L.

Chemia Analityczna

2004

Vol. 49, No. 5

643-652

A flow-injection chemiluminescence method for the determination of tobramycin, micro-nomicin, amikacin and gentamycin has been described. The method utilises chemilumines-cence of the above analytes emitted during their oxidation with N-bromosuccinimide (NBS) in alkaline medium in the presence of fluorescein. The obtained detection limits (3 Sigma) are 0.07 ug mL(-1): for tobramycin and 0.08 ug ml/1 for micronomicin, amikacin and gentamycin. The evaluated method is recommended for automated and continuous analysis- In the automated mode the samples can be analysed at the rate of 100 per h with RSD of about 2.0% for the determination of 5 ug mL (-1) of each aminoglycoside antibiotic (n= 11). The proposed method has been successfully used for the analysis of commercial pharmaceutical formulations without any sample pretreatment.

Opisano przepływową, chemiluminescencyjną metodę oznaczania tobramycyny, mikrono-mycyny, amikacyny i gentaraycyny. W metodzie tej wykorzystano chemiluminescencję powstającą podczas utleniania analitów NBS w środowisku alkalicznym, wobec fluoresceiny. Otrzymane progi wykrywalności (3 o) wynosiły 0,07 ug mL (-1) dla tobramycyny i 0,08 ug mL(-1) dla mikronomycyny, amikacyny i gentamycyny. Opracowana metoda jest polecana do analiz zautomatyzowanych i ciągłych. W systemie zautomatyzowanym próbki mogą być analizowane z szybkością 100 na godziną z RSD ok. 2% dla 5 ug mL(-1) każdego antybiotyku aminoglikozydowego (n = 11). Proponowana metoda została z powodzeniem zastosowana do analizy formulae] i farmaceutycznych bez wstępnej obróbki próbki.

Cyklitole

Frankowski R., Maszewski W., Smiatacz Z.

Wiadomości Chemiczne

2001

[Z] 55, 9-10

821-848

Cyclitols constitute important structural elements of a variety of biologically active compounds, such as aminoglycosides antibiotics, phospholipid inositols referred to as "secondary messengers", and coordination compounds with metals, e.g. platinum, interest in many areas of natural sciences. In spite of the fact that cyclitols have been known since the 18th century, the majority of significant achievements in this field is seen during the late 90-ties of the 20th century. The first section of this review deals with general information on the nomenclature, structural features, configuration and conformation of the cyclitols. The second section is concerned with the occurrence and biological properties of the inositols, in particular of myo-inositol and its derivatives. A mechanism of action of myo-inositol 1,4,5-triphosphate (1,4,5-IP3) as a secondary messenger has been outlined in Scheme 9. The third section discusses the occurrence and biological activity of the other cyclitols of structures illustrated by the formulae in Schemes 10 through 15. The fourth section is confined to aminocyclitols antibiotics. Their names occurrence, mode of action and formulae of main representatives of this class of compounds are summarized in Table 3 and in Figs. 1 through 8. The last section descibes common methods of preparation of the cyclitols. These are as follows: (i) syntheses using sugar precursors; (ii) syntheses utilizing the Diels-Alder cycloaddition (iii) hydrogenation of polyhydroxybenzenes; (iv) molecular modification of known cyclitols.