The chromatographic-densitometric method was developed for the simultaneous determination of various pharmaceutical agents, such as haloperidol, fluxetine, promazine, doxepin, clonazepam, alprazolam, and risperidone in biological material. Two mobile phases, A (acetone-diethylamine-cyclohexane (2.5:2.5:20, υ/υ/υ)) and B (trichloromethane-acetone-25% NH3 (25:25:0.5, υ/υ/υ)), were used for the separation of the above-mentioned compounds. Silica gel-covered F254 TLC plates were used as stationary phases. Densitometric recording was carried out at 254 nm wavelength. Well-developed peaks, easy to quantify, and quality analysis were obtained after achieving the separation of compounds in the developed conditions. It was demonstrated that the presence of a matrix (plasma or urine) did not affect the shape of the peaks and their localization on the chromatograms.
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