Wyniki wyszukiwania - BazTech

1

Development and validation of LC-MS/MS method for determination of plasma apixaban

Dzudovic Jelena, Crevar Sakac Milkica, Antunovic Marko, Repic Aleksandra, Obradovic Slobodan, Djordjevic Snezana, Savic Jelena, Dzudovic Boris

Acta Chromatographica

|

2022

|

Vol. 34, no. 3

332--337

EN

Oral anticoagulants are a group of drugs used for the prevention and treatment of venous thrombosis and venous thromboembolism. For the last ten years, direct oral anticoagulants (DOAC) have been available and are equally effective, but significantly safer than vitamin K antagonists. In the case of an overdose, their most important side effect is still bleeding. Due to their widespread use, as well as increased toxicological importance there is a need to develop an analytical method for the determination of DOAC in biological material. The aim of this paper was to establish a method for the quantification of apixaban as one of the representatives of DOAC. The methodology of the study included the measurement of apixaban in the plasma of patients treated in the intensive care unit. Plasma apixaban concentrations were determined by LC-MS/MS technique using carbamazepine as an internal standard. Obtained validation parameters indicate that the introduced method is sensitive, reliable, precise and accurate. Using this method, apixaban can be quickly and easily detected and quantified in plasma in patients who are suspected of overdosing with this drug.

2

Nowe kierunki badań i wyzwania w analizie leków heparynowych

Sadowski Radosław, Krysztofiak Dominika, Gadzała-Kopciuch Renata, Buszewski Bogusław

Wiadomości Chemiczne

|

2021

|

[Z] 75, 7-8

935--942

EN

The complexity of the structure of heparin anticoagulants requires appropriate sample preparation to be able to perform the analysis correctly. This stage of the analytical procedure is the most time-consuming and has a key impact on the obtained information. Therefore, it is important to improve the current and search for new solutions for the preparation of samples of anticoagulants as well as the separation and identification of components of such drugs. This paper discusses heparin drugs and new research directions and challenges related to the analytics of heparin anticoagulants.

3

Polymeric anticoagulants based on poly(2-(acryl-amido)-2-methylpropane-sulfonic acid) block polymers

Szczubiałka K., Kałaska B., Kamiński K., Mikłosz J., Yusa S., Sokołowska E., Błażejczyk A., Wietrzyk J., Pawlak D., Nowakowska M., Mogielnicki A.

Engineering of Biomaterials

|

2017

|

Vol. 20, no. 143 spec. iss.

73

4

Dodatki do probówek w medycznych laboratoriach diagnostycznych

Bergmann K.

Laboratorium - Przegląd Ogólnopolski

|

2013

|

nr 7-8

24--27

PL

Prawidłowy dobór oraz pobranie materiału biologicznego mają kluczowe znaczenie dla właściwego wykonania badania laboratoryjnego oraz otrzymania wiarygodnego wyniku. W pracy opisano powszechnie stosowane dodatki do probówek do pobierania krwi - antykoagulanty, aktywatory/inhibitory oraz dodatki separujące.

EN

Proper selection and collection of biological material is crucial for the performance of laboratory test and to obtain reliable results. This paper describes commonly used additives to blood collection tubes - anticoagulants, activators/inhibitors and separating substances.