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1

Diagnostyka serologiczna w zakażeniach SARS-CoV-2

Jońca Mateusz, Krótki Filipina, Tomasik Przemysław

Laboratorium Medyczne

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2020

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nr 2-3

15--19

PL

Badania serologiczne w wykrywaniu aktywnej choroby COVID-19 nie mają dużego znaczenia. Jednak przy wzrastającej liczbie chorych bezobjawowo, którzy nie są diagnozowani, jest to jedyna możliwość retrospektywnej oceny tego zjawiska oraz wnioskowania o odporności stadnej. Aktualnie prowadzone niezależne walidacje pozwalają wskazać najbardziej wiarygodne testy laboratoryjne i do wykorzystania w miejscu opieki.

EN

Serological tests are not useful in diagnosing active COVID-19 disease. However, with the increasing number of asymptomatic patients who are not recognized, this is the only way to retrospectively evaluate this phenomenon and to infer about herd immunity. Currently conducted independent validations allow to indicate the most reliable laboratory as well as POCT tests.

2

Quantum dots and their immunochemical applications

Malik A., Kurczewski M., Majak I.

Biotechnology and Food Science

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2016

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Vol. 80, nr 2

137--149

EN

Quantum dots (QDs) are nanometre size semiconductor crystals which possess unique physical and chemical properties. In recent years they were widely used as signal enhancers in biological analysis, mainly because of their high quantum yield, photostability and long-lasting photoluminescence. Compared to common organic fluorophores QDs exhibit wider absorption spectra (QDs absorb photons when excitation energy exceeds the bandgap), narrow emission wavelengths and high Stoke’s shift which allow usage of several different-coloured QDs in single multiplex assays. QDs’ synthesis can be conducted by top-down or bottomup approach. Both methods of synthesis may lead to surface imperfections which may negatively affect QDs’ optical properties. To avoid this problem surface passivation is required. The most widely used passivation method is to cover the QD’s core with material having larger band gap (ZnS). QDs can be widely used in different applications due to the ease of surface functionalization by means of organic and inorganic molecules (polymers, dendrimers, proteins, antibodies and etc.) by many different approaches like ligand-exchange, silanization, amphiphilic combination and other mechanisms. Functionalized QDs have been used for various purposes in in-vitro and in-vivo imaging, drug delivery, therapeutics and other. However this review is mainly focused on immunochemical applications of QDs such as immunohistochemistry, FLISA, FRET, immunosensors etc. QD-based immunological assays are being used for detection of pathogens, toxins, proteins, metal ions (Hg2+) and allergens. Based on growing rate of QDs’ applications it can be concluded that in the coming years their number is going to increase.

3

The immune method for classifying objects on the basis of the target clonal selection

Korablyov M., Fomichov O., Kushnaryov M., Wójcik W.

Elektronika : konstrukcje, technologie, zastosowania

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2013

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Vol. 54, nr 8

36-39

PL

W pracy omawiany jest algorytm klasyfikacji immunologicznej, który działa w oparciu o model selekcji klonalnej, z wykorzystaniem konkurencyjnego klonowania sekwencyjnego w zakresie wyboru celu. Skoncentrowano się na mutacji operatorów i wstępnej selekcji oraz, zasad doboru antygenów docelowych. Do klasyfikacji przeciwciał, które nie były głównym wyborem zaproponowano użycie przeciwciał-delegatów ze znanymi, należącymi do klas metodami.

EN

In this paper considered the immune object classification algorithm that works on the model selection of clones using sequential cloning competitive-target selection. The focus is on the mutation operators and the primary selection, principles of selection of target antigens. For the antibodies classification that have not been the primary selection we proposed using antibodies-delegates with known methods, belonging to classes.

4

Behaviour of Solutions to Marchuk's Model Depending on a Time Delay

Bodnar M., Foryś U.

International Journal of Applied Mathematics and Computer Science

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2000

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Vol. 10, no 1

97-112

EN

Marchuk's model of an immune reaction is a system of differential equations with a time delay. The aim of this paper is to study the behaviour of solutions to Marchuk's model depending upon the delay of immune reaction and the history of an illness. We study Marchuk's model without delays, with aconstant delay and with an infinite delay. A continuous dependence on thedelay is considered. Bifurcation points are found using computer simulations.