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EN
1-(naphthalen-2-yl)-2-(1H-pyrazol-1-yl) ethanone (MPPY) was synthesized. The structure was characterized by spectral analysis (1H-NMR, FT-IR). The molar absorptivity of MPPY is high enough, similarly to acetonaphthone derivatives, to be used as an efficient type I photoinitiator. The influence of MPPY concentration and the addition of the co-initiator N-methyldiethanolamine (MDEA) on methyl methacrylate (MMA) polymerization were also investigated. Additionally, MPPY showed good antibacterial activity against Escherichia coli and Staphylococcus aureus (diffusion method).
PL
Zsyntetyzowano 1-(naftalen-2-ylo)-2-(1H-pirazol-1-ylo)etanon (MPPY). Strukturę scharakteryzowano metodą analizy spektralnej (1H-NMR, FT-IR). Molowa absorpcja MPPY jest na tyle wysoka, że można go stosować, podobnie jak pochodne acetonaftonu, jako skuteczny fotoinicjator typu I. Zbadano również wpływ stężenia MPPY oraz dodatku koinicjatora N-metylodietanoloaminy (MDEA) na polimeryzację metakrylanu metylu (MMA). Dodatkowo MPPY wykazywał aktywność przeciwbakteryjną w stosunku do Escherichia coli i Staphylococcus aureus (metoda dyfuzji).
EN
Various types of metal implants, both in Poland and worldwide, are mainly manufactured from stainless steel due to their biocompatibility, strength, and relatively low price. However, any such procedure involves the risk of peri-implant infection, stimulated, among other things, by the formation of a bacterial biofilm on the surface of the implant. In this paper, several methods of modifying the surface of steel for medical applications were proposed, such as mechanical polishing, electropolishing, sandblasting, and the application of a thin surface layer. This was followed by a series of physicochemical and biological tests. The results indicate that the titanium nitride coating improved corrosion resistance and reduced bacterial adhesion on the surface. No significant improvement in abrasion was observed, and the adhesion of the coating closely depended on the method of preparation.
PL
Implanty metalowe, zarówno w Polsce, jak i na świecie, produkowane są głównie ze stali nierdzewnej ze względu na jej biokompatybilność, wytrzymałość i stosunkowo niską cenę. Jednak każdy tego rodzaju zabieg wiąże się z ryzykiem powstania zakażenia okołowszczepowego, stymulowanego m.in. powstawaniem biofilmu bakteryjnego na powierzchni implantu. W pracy zaproponowano kilka metod modyfikacji powierzchni stali do zastosowań medycznych, takich jak polerowanie mechaniczne, elektropolerowanie, piaskowanie oraz nałożenie cienkiej warstwy powierzchniowej. Następnie przeprowadzono szereg badań fizykochemicznych i biologicznych. Wyniki wskazują, że powłoka azotku tytanu poprawiła odporność na korozję oraz ograniczyła adhezję bakterii na powierzchni. Nie zaobserwowano znaczącej poprawy ścieralności, a adhezja powłoki ściśle zależała od metody jej przygotowania.
EN
The presented article describes the method of synthesizing new ionic liquid based on a biguanide cation and a tiocyanate or benzoate anion with antimicrobial properties. The structure of obtained new ionic liquid was confirmed by infrared spectroscopy. Additionally, the article describes a simple method of producing an antibacterial textile materials and PE-based film with the addition of an ionic liquid.
EN
Materials used in bone implants should not only be non- -toxic to the surrounding tissues, but also should promote osseointegration and minimize the risk of infection. Infections are a serious problem contributing to implantation failure. They are associated with pain, immobilization, and the necessity of reoperation. In extreme cases, they can lead to significant inflammatory changes in the bones, which, in turn, can lead to amputation and even death. After implantation, the surrounding tissues are damaged. In addition, implants are susceptible to bacterial colonization due to the lack of microcirculation. Therefore, scientists are working on antibacterial coatings to prevent the adhesion of bacteria before tissue regeneration. The paper concerns the biological and mechanical properties of titanium implants with an antibacterial coating. The Ti13Zr13Nb alloy samples were coated with hydroxyapatite (HAp) coatings using the electrophoretic deposition technique (EPD). Subsequently, the surface of the samples was modified with silver, copper, and nickel nanoparticles by the immersion method. Different titanium sample types (i.e. HAp-only and nanometals-enriched coatings) were placed in a bacterial solution for a period of one month. Each sample was examined using scanning electron microscopy (SEM), nanoindentation, nanoscratch, and contact angle tests. The significant amount of dead biofilm on the surface proves the effectiveness of antibacterial activity. The wettability assessment showed that the samples were hydrophilic. The conducted tests of mechanical properties indicate the heterogeneity of the coatings.
6
Content available Biocidal properties of copper nanoparticles
EN
Metal nanoparticles (NPs) with antibacterial properties represent a promising alternative approach to antibiotics, whose overuse has led to the appearance of drug-resistant bacteria. This article addresses particularly copper (Cu) nanoparticles since Cu is a structural constituent of many enzymes in living microorganisms. In addition, Cu has a better antibacterial effect and minimal cost compared to silver. The properties of Cu nanoparticles are described here: antibactericide, toxicity mechanisms, oxidation, and copper oxide biocompatibility for medical applications. Along with the advantages of Cu nanoparticles, the nanotoxicity still remains to take into consideration such as in targetting different bacteria strains, bacteria’s resistance, the effect of size, the effect of NP chemical composition, the effect of oxidation, and the corona phenomenon effect. The methodology of Cu nanoparticles synthesis, related to the biocidal effect, is illustrated by some limitations and some breakthrough such as chitosan stabilizer (CS), laser ablation, plasma induction, and flow-levitation method (FL). Although Cu nanoparticles are beneficial for bacterial elimination, these nanoparticles are graded harmful to the human body and the environment because of their toxic effects. Thus, it requires further improvement and further investigation to create super antibacterial Cu nanoparticles, to develop some interesting research work around this subject, and to reveal some promising medical findings.
EN
The problem of treating chronic wounds is widespread throughout the world and carries a huge cost. Biomaterials engineering tries to solve this problem by creating innovative bioactive dressings dedicated to specific types of wounds. Both synthetic and natural polymers are the main base to produce wound dressings. Biopolymers have the advantage over synthetic polymers by being more biocompatible, non-toxic, biodegradable, and eco-friendly. The aim of this work was to produce a bioactive biomaterial based on natural polymers with potential applications to manage chronic highly exuding and infected wounds. A newly developed method for chemical synthesis of the curdlan/agarose biomaterial at high temperature combined with freeze-drying process resulted in a superabsorbent dressing material with antibiotic immobilized. The obtained biomaterial was subjected to basic microbiological in vitro tests and a cytotoxicity assay according to ISO 10993-5. Moreover, the experimental treatment of the infected wound in a veterinary patient was performed using the developed material. Based on the conducted research, it was proved that the produced dressing is not toxic to normal human skin fibroblasts. An additional advantage of the biomaterial is its ability to inhibit the growth of harmful microorganisms, such as Staphylococcus aureus and Pseudomonas aeruginosa. Furthermore, the experimental treatment confirmed the validity of using the produced biomaterial as a dressing dedicated to the treatment of difficult-to-heal infected wounds. To summarize, the produced biomaterial possesses great potential to be used as a wound dressing for infected wounds.
EN
This study discusses the effect of corona pretreatment and subsequent loading of titanium dioxide nanoparticles on self-cleaning and antibacterial properties of cellulosic fabric. The corona-pretreated cellulosic fabrics were characterized by fi eld emission scanning electron microscopy, and X-ray mapping techniques revealed that layers of the titania deposited on cellulose fi bers were more uniform than the sample without pre-corona treatment. The self-cleaning property of treated fabrics was evaluated through discoloring dye stain under sunlight irradiation. The antibacterial activities of the samples against two common pathogenic bacteria including Escherichia coli and Staphylococcus aureus were also assessed. The results indicated that self-cleaning and antibacterial properties of the corona-pretreated fabrics were superior compared to the sample treated with TiO2 alone. Moreover, using corona pretreatment leads to samples with good washing fastness.
EN
The effect of the amount of pine needle oil on the properties of rigid polyurethane (RPUF) foams was investigated. The influence of pine needle oil content on the cellular morphology, physical, mechanical, and antibacterial properties of RPUF was evaluated. The addition of pine needle oil had decreased the dynamic viscosity and processing times of polyurethane (PUR) systems. It was found that the foams containing 5 wt % of pine needle oil had better mechanical properties, e.g. compressive strength, flexural strength, and impact strength. RPUF containing the highest concentration of pine needle oil, such as 15 wt %, possessed improved antibacterial activity against E. coli and S. aureus. This study confirmed that the use of pine needle oil is an effective approach to the production of RPUFs with antibacterial activity.
PL
Zbadano wpływ dodatku olejku sosnowego na właściwości użytkowe sztywnych pianek poliuretanowych (RPUF): strukturę, właściwości fizyczne, mechaniczne i antybakteryjne. Układy poliuretanowe (PUR) modyfikowane dodatkiem olejku sosnowego charakteryzowały się mniejszą lepkością dynamiczną oraz krótszymi czasami syntezy niż układy bez dodatku. Najlepsze właściwości mechaniczne, w tym m.in. wytrzymałość na ściskanie, zginanie trójpunktowe i udarność, wykazywała pianka poliuretanowa zawierająca 5% mas. olejku sosnowego. Najlepszymi właściwościami antybakteryjnymi (względem E. coli oraz S. aureus) odznaczała się pianka zawierająca 15% mas. olejku sosnowego. Stwierdzono, że modyfikacja układów poliuretanowych dodatkiem olejku sosnowego umożliwia otrzymanie RPUFs o właściwościach antybakteryjnych.
EN
This paper addresses the issue of plasma treatment of the surface of polypropylene (PP) using sputtering of silver (Ag) and copper (Cu) and their oxides with MS-PVD in order to impart antimicrobial activity. It was found that plasma treatment of PP with Cu and Ag based layers allows to provide excellent antimicrobial properties due to a constant release of metal ions. The samples of PP treated with Cu and CuO were characterized by highest antimicrobial properties and stability of the coatings. The most stable and least effective coating against bacteria was Ag-PP sample. In turn, AgO-PP was characterized by the lowest stability in aqueous conditions and strong antimicrobial activity. It was found that leaching of metal ions from the surface of treated PP even in exceptional levels plays a crucial role in bactericidal activity.
PL
Niniejsza praca dotyczy plazmowej obróbki powierzchni polipropylenu (PP) przy użyciu miedzi (Cu) i srebra (Ag) oraz ich tlenków. Powłoki Cu, CuO, Agi AgO, wytworzone na powierzchni PP metodą rozpylania magnetronowego MS-PVD, zbadano pod względem morfologii, składu, stabilności i właściwości antybakteryjnych. Materiały powierzchniowo zmodyfikowane przy użyciu Cu i CuO charakteryzowały się najsilniejszymi właściwościami przeciwbakteryjnymi i najmniejszą stabilnością i trwałością w środowisku wodnym. Powłoka AgO wykazywała najmniejszą stabilność w warunkach wodnych i silną aktywność przeciwbakteryjną, natomiast powłoka Ag wykazywała największą stabilność, a zarazem najsłabsze działanie przeciwbakteryjne. Uzyskane wyniki wskazują, że uwalniane z naniesionych powłok jony, nawet w niewielkim stężeniu, wykazują silne działanie antybakteryjne.
EN
Purpose: The influence of UV radiation on the antibacterial properties of titanium oxide nanoparticles was examined using yeast Saccharomyces cerevisiae strain for this purpose. Design/methodology/approach: Nanopowders were made with sol-gel method. Surface morphology studies of the obtained materials were made using Zeiss's Supra 35 scanning electron microscope. In order to confirm the chemical composition of observed nanopowders, qualitative tests were performed by means of spectroscopy of scattered X-ray energy using the Energy Dispersive Spectrometer (EDS). The DLS (Dynamic Light Scattering) method was used to analyse the particle size distribution using the AntonPaar Litesizer 500 nanoparticle size analyser. Changes in particle size distribution at elevated temperatures were also observed. The antibacterial properties of titanium oxide nanoparticles were examined by subjecting the yeast sample to irradiation with an UV lamp. Findings: Samples containing yeast Saccharomyces cerevisiae were irradiated with and without the addition of TiO2 nanoparticles. A faster decrease in the colony count was observed compared to irradiated exposures without the addition of a suspension. Practical implications: Presented materials can be used in the production of antibacterial coatings for surfaces occurring in public spaces such as schools, hospitals, public toilets for the simple and effective elimination of bacteria and fungi as a result of exposures. Originality/value: The antibacterial properties of titanium oxide nanoparticles under UV radiation were confirmed.
EN
The paper presents the results of a study investigating the impact of reduced graphene oxide (RGO) on selected mechanical and functional properties of LDPE foils. The foils were made by blow extrusion, with different amounts of RGO added to the granules prior to the extrusion process. The mechanical properties of foil samples were assessed in a static tensile test, and their bacterial resistance was tested. The impact of RGO on antibacterial interactions and the desirable mechanical properties of the foils was analyzed. The results of this study supported the selection of the most advantageous solution for industrial applications.
EN
Biofouling is a phenomenon that adversely affects the efficiency of filtration hindering wide the application of filtration materials. One of the methods for biofouling prevention is coating of antibacterial nanoparticles on a surface of filters and membranes using ultrasound. In the paper, the possibility of using an ultrasonic method was evaluated to implement nanoparticles of titanium dioxide (TiO2 ) and zinc oxide (ZnO) on polymeric filtration materials via different types of transducers and selected parameters of the ultrasound generator. Ultrasonic methods of modification were found to be efficient in terms of imparting antibacterial properties; however, the functional additives coated on polymeric materials were characterized by poor resistance to leaching. Thus, further work needs to be performed to improve the adhesion and stability of nanoparticles onto polymeric materials to enable the generation of filtration materials characterized by high stability during real operating conditions.
PL
Biofouling materiałów filtracyjnych jest zjawiskiem niekorzystnie wpływającym na efektywność filtracji i hamującym wprowadzanie tej technologii w nowe obszary zastosowań. Jedną z metod zapobiegania biofoulingowi jest modyfikacja powierzchni membran antybakteryjnymi nanocząstkami. W artykule opisano prace studialne nad wykorzystaniem do tego celu metody nanoszenia ultradźwiękowego. Przedstawiono konstrukcje i parametry zestawionych stanowisk do generacji ultradźwięków, wyniki procesów nanoszenia nanocząstek tlenku tytanu i tlenku cynku, wpływ głównych parametrów procesu na strukturę uzyskiwanych pokryć. Oceniono ich właściwości antybakteryjne oraz odporność na wymywanie. Określono kierunki dalszych prac mających na celu wytworzenie metodą ultradźwiękową materiałów filtracyjnych charakteryzujących się stabilno- ścią podczas pracy w warunkach rzeczywistych.
EN
The novel technique that will be introduced for modifying surfaces is plasma treatment, which creates a great potential in the development of a variety of functional properties of polymeric membranes. Application of this technique in the processes of membrane modification allows functionalization by the manufacturing metal oxides such as copper oxide, silver oxide, or titanium dioxide on the surface. In this work, the polymeric membranes were activated with low-temperature plasma of different gases (Ar and Ar-O2 ) and subjected to copper oxide deposition. The leaching of copper from the surface of plasmamodified membranes and its permeability and antimicrobial activity were examined. It was found that CuO-modified membranes pre-activated in an Ar or Ar-O2 mixture are characterized by much lower stability than ones without pre-activation. Moreover, the filtration properties of CuO-modified membranes were unchanged compared to native ones, and these filtration materials are characterized by antibacterial properties.
PL
Techniki plazmowe to nowatorskie metody modyfikacji powierzchni, które umożliwiają nadanie różnorodnych właściwości funkcjonalnych membranom polimerowych. Zastosowanie technik plazmowych podczas modyfikacji membran polimerowych umożliwia ich funkcjonalizację poprzez wytwarzanie tlenków metali, takich jak tlenek miedzi, tlenek srebra lub dwutlenek tytanu na ich powierzchniach. W ramach przeprowadzonych prac membrany polimerowe aktywowano niskotemperaturową plazmą w mieszaninie w różnych gazów (Ar i Ar-O2 ), które następnie poddawano modyfikacji przy użyciu tlenku miedzi. Zbadano stabilność związania tlenku miedzi z powierzchnią membran modyfikowanych plazmą i jej przepuszczalność oraz aktywność przeciwdrobnoustrojową. Stwierdzono, że membrany modyfikowane CuO wstępnie aktywowane w Ar lub mieszaninie Ar-O2 charakteryzują się znacznie mniejszą stabilnością niż te bez wstępnej aktywacji. Ponadto właściwości filtracyjne membran modyfikowanych CuO były niezmienione w porównaniu z materiałami natywnymi, a wytworzone materiały filtracyjne charakteryzowały się właściwościami antybakteryjnymi.
EN
The quinolones are synthetic antibiotics derived from nalidixic acid. Chemical modification of basic structure (nalidixic acid) has led to the development of a group of various compounds currently used in medicine. This article discusses the generation of quinolones, mode of their action, and relationship between activity and structure of these antibiotics. The most common quinolones, lomefloxacin and sparfloxacin were discussed in details, also the therapeutic potential of newer agents was reviewed. Recently, understanding of how molecular modifications among quinolone core structure can affect antimicrobial and anticancer activities has progressed rapidly. In this paper we discussed few examples of fluoroquinolone structural modifications. It was proved that many organic and inorganic compounds derived from fluoroquinolones overcame bacterial drug-resistance. Furthermore, chemical modification improved fluoroquinolone’s anticancer activities.
EN
Polyethylene oxo-degradable composites containing antibacterial substances in the form of vegetable oils: geranium, clove and eucalyptus as well as a mixture of nanoAg with nanoCu were discussed. Antibacterial film: PE-0, PE- 1A, PE-2B, PE-3C, PE-4D properties were verified according to ISO 22196:2011 “Measurement of antibacterial activity on plastic and other non-porous surfaces” for the two standard bacteria species of E. coli and S. aureus, whereas water vapour permeability tests (Pv) were carried out acc. ISO 15106-2007 “Plastics. Foils and plates. Determination of water vapor transmission rate. Part 1: Humidity sensor method”. Film marked PE-4D showed the best antibacterial features and good barrier properties.
EN
The aim of this research was to examine the influence of process parameters of low-temperature plasma treatment on the permeability, stability, and antibacterial properties of polyamide membranes. As a result of the work, the process conditions were selected for plasma deposition of copper oxide, which enable the high stability of the copper oxide coatings on the filtration materials characterized by efficient permeability and antimicrobial activity. Further work is necessary to examine new generation filtration materials in real process conditions for industrial post-consumer liquids. This can contribute to the implementation of the new generation filtration materials proposed in this work.
PL
W pracy przedstawiono wyniki badań dotyczące wpływu parametrów procesowych niskotemperaturowej plazmowej obróbki powierzchni membran poliamidowych na przepuszczalność, stabilność i właściwości antybakteryjne wytworzonych materiałów filtracyjnych. W rezultacie przeprowadzonych eksperymentów dobrano warunki procesowe plazmowej obróbki tlenkiem miedzi, które umożliwiają wytworzenie stabilnych materiałów filtracyjnych charakteryzujących się wysoką przepuszczalnością i właściwościami antybakteryjnymi. Konieczne są dalsze prace umożliwiające zbadanie zachowania wytworzonych materiałów filtracyjnych w rzeczywistych warunkach procesowych przy użyciu ścieków przemysłowych. Dopiero takie działania mogą przyczynić się do udanej komercjalizacji rozwiązania materiałowego zaproponowanego w niniejszej pracy.
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