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Antybakteryjne i atrombogenne włókna poliestrowe

Karaszewska A.

Zeszyty Naukowe. Włókiennictwo / Politechnika Łódzka

2008

z. 64

59-71

Opracowano metodę otrzymywania implantów medycznych z poli(tereftalanu etylenowego) PET o właściwościach antybakteryjnych i atrombogennych, na które są wrażliwe bakterie Gram+ i Gram-. Metoda polegała na dwustopniowej modyfikacji implantów, w której w znikomych ilościach powstaje produkt uboczny, zatem metoda ta jest praktycznie bezodpadowa. Przeprowadzono wstępne badania (in vivo), działania drażniącego oraz zbadano właściwości atrombogenne modyfikowanych wyrobów. Stwierdzono, że nici chirurgiczne PET oraz protezy naczyniowe, zawierające w swej budowie biocyd przyłączony wiązaniem chemicznym, są w dużym stopniu aktywne w stosunku do bakterii Gram+ i Gram-.

In order to provide polyester with antibacterial and atrombogenic properties, a two-stage modification of polyester yarn, surgical threads and vascular prothesis was carried out. Modification was based on introducing macromolecules into the polymer of carboxylic group through grafting them with PAA or PMA - I stage. In the second stage of modification, the grafted products were imbued with biocide solution from amiglicozyde group (Amikacin), which are derivatives of penicillin (Amoxycylline) and silver ions derived from non-organic salts - (each biocide separately). A method of modification of surgical threads add knitted vascular prothesis was established, where only slight amount of by-product is created, thus the method is virtually waste-free. Throughout the simulation tests, kinetics of biocide release to water and an appropriate buffer or physiological salt from modified products was tested, assuming that any release of the drug under the influence of tissue liąuids creates a possibility of inhibiting the growth of microorganisms, therefore also creating a possibility of preventing post-operation infections. During the in vitro tests, antibacterial character of modified products was established against Gram+ and Gram- bacteria, which are typical for the hospital conditions. There were also some introductory (in vivo) tests of irritating action carried out and additionally, atrombogenic properties of modified fibres were tested. It was stated that surgical PET threads that include antibiotic in their structure are active on a wide scalę towards Gram+ and Gram- bacteria. Antibiotics or Ag+ released from surgical threads are easily absorbed in tissue environment, making the wound heal without exudations or inflammations. There were also the following measurements taken: electrokinetic potential, water permeability and hydrophilic character of the modified fibres of vascular prothesis.