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Properties and Applications of Essential Oils: A Review

Żukowska Grażyna, Durczyńska Zofia

Journal of Ecological Engineering

2024

Vol. 25, nr 2

333--340

Essential oils are complex mixtures of volatile compounds obtained from plants where they play aromatic, communicative and defensive roles. They have been used for centuries in medicine, agriculture and industry due to their broad spectrum of biological activity. They exhibit antimicrobial, antiviral, anti-inflammatory, antioxidant and smooth muscle relaxant properties. Due to their lipophilicity and small molecular size, essential oil components easily penetrate biological membranes and exert therapeutic effects. Currently, research is underway on the use of essential oils for the treatment of viral infections, cancer prevention and inflammatory diseases. These agents may provide a valuable alternative to conventional therapies due to their natural origin and high tolerability. However, ensuring the appropriate quality and standardization of preparations is crucial to guarantee their efficacy and safe use. This paper provides an overview of the properties of essential oils, the methods used to obtain them, their composition, and their medical and therapeutic applications.

Pochodne 1,2,3-triazolu. Potencjalne leki?

Bankowska E., Wróblewski A. E.

Wiadomości Chemiczne

2012

[Z] 66, 11-12

993-1022

Recently, 1,2,3-triazoles have gained an increased attention in the field of drug discovery because several derivatives have already been marketed as medications (e.g. tazobactam, cefatrizine, rufinamide) [1, 2] and many of them appeared to be very active in diverse biological studies including plinambulin 69 currently in the last stage of the clinical trials [60]. In this review very recent investigations of antibacterial, antitubercular, antifungal, antipsychotic, antiepileptic, anti-inflammatory, hypoglycemic, anticancer and antiviral properties of 1,2,3-triazole derivatives are discussed. These studies allowed to select several compounds which were found to be more active in comparison to the already used drugs.

Reactions of 5-(2-Dimethylamino-6-methyl-4-pyrimidinylsulfanylmethyl)-1,3,4-oxadiazole-2-thione with carbon Electrophiles

Burbuliene M., Udrenaite E., Gaidelis P., Vainilavicius P.

Polish Journal of Chemistry

2002

Vol. 76 / nr 4

557-563

From 2,4-dichloro-6-methylpyrimidine (1) via esters 2 and 3, (2-dimethylamino-6- methyl-4-pyrimidinylsulfanyl)acethydrazide (4) was synthesized. The latter under treatment either with carbon disulfide in the presence of a base or with potassium O-ethylxanthate in ethanol yielded 5-(2-dimethylamino-6-methyl-4-pyrimidinylsulfanylmethyl)-1,3,4- oxadiazole-2-thione (5). Alkylation of 5 afforded S-alkyl derivatives 6a,b, whereas aminomethylation, acylation or cyanoethylation gave N(3)-substituted derivatives 7-9. Compounds were tested for their anti-inflammatory activity.