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TLC–Densitometry analysis of indole compounds in mycelial culture of Imleria badia and Agaricus bisporus enriched with precursors — serine or anthranilic acid

Opoka W., Kała K., Krężałek R., Sułkowska-Ziaja K., Maślanka A., Muszyńska B.

Acta Chromatographica

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2018

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Vol. 30, no. 4

236--242

EN

Agaricus bisporus and Imleria in vitro cultures were cultivated on modified Oddoux medium, and Oddoux medium was enriched with serine or anthranilic acid. Serine or anthranilic acid was used at the concentrations of 0.1, 0.25, 0.5, and 0.75 g/L of medium. Determination of indole compounds in the obtained biomass was carried out using thin-layer chromatography (TLC) with densitometric detection. In every analyzed sample, presence of serine or anthranilic acid was studied. Comparison of the results obtained for the treatment and control samples allowed us to determine the optimum concentration of serine or anthranilic acid in the medium in order to obtain biomass with increased content of indole compounds. A. bisporus with addition of anthranilic acid or serine to the medium at the concentration of 0.5 g/L was the most beneficial. In the case of Imleria badia, anthranilic acid at the concentration of 0.5 g/L was the most optimal. This is the first report demonstrating the content of indole derivatives in biomass affected by their precursors (serine or anthranilic acid). The study indicates that modification of the medium can provide satisfactory results, and it is worth to search for its new, improved compositions.

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Reakcja Niementowskiego

Łysakowska M., Piotrowska D. G.

Wiadomości Chemiczne

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2015

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[Z] 69, 5-6

369--390

EN

The Niementowski reaction depends on the fusion of anthranilic acid with carbonyl compounds or amides and dates back to the end of the nineteenth century. Numerous variations of the reaction components and modifications of the reaction conditions have appeared in the literature through years. Besides anthranilic acid other synthons including: methyl o-aminobenzoate [25], o-nitrobenzoic acid [26], o-acylaminobenzamide [21], o-aminobenzamide [27], o-aminobenzonitrile [28], isatoic anhydride [29], benzoxasinone [30, 31] have been employed as well. Replacement of the amide component with either amine [9, 32], nitrile [33], imidate [34], thioamide [35], amidine [36], aldehyde [37] or carboxylic acid [28] have also been reported. To increase yield and to reduce the reaction time a number of variables in reaction conditions have been investigated. The best results have been achieved by implementation of a microwave irradiation [38]. The Niementowski reaction and its variants have found widespread use in pharmaceutical and agrochemical fields for the synthesis of compounds containing quinoline and quinazoline systems which are present in a number of natural and synthetic alkaloids [12, 13] and many drugs [1–5].

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Studies on the Interaction of Transition Metal Complexes of the Schiff Base Derived from Anthranilic Acid and Acetoacetanilide with DNA

Raman N., Rajasekaran K.

Polish Journal of Chemistry

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2007

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Vol. 81, nr 2

149-159

EN

Four neutral complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been prepared with a new tridentate Schiff base (HL) derived from anthranilic acid and acetoacetanilide. The analytical data show that themetal to ligand ratio is 1:2. The structural features have been determined from IR, UV-Vis, 1H-NMR, ESR and mass spectral data. All the complexes exhibit octahedral geometry around the central metal ion. Their low electrical conductance values support their neutral nature. The magnetic moment data provide evidence for the monomeric nature of the complexes. Absorption experiments have been carried out on the interaction of the complexes with calf thymus DNA (CT-DNA). The results suggest that all the complexes can bind to CT-DNA by intercalation between chromophore and DNAbase pairs. An electrochemical study of the copper complex reveals that it prefers to bind to DNA in the Cu(II) rather than the Cu(I) oxidation state. The nucleolytic cleavage activity of all the complexes was examined on CT-DNA by using a gel electrophoresis experiment in the presence and absence of oxidant, H2O2. In the absence of the oxidant, a less discernible DNAcleavage was observed, whereas in the presence of the oxidant, all complexes showed enhanced nuclease activity.

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Facile Synthesis of 2-Substituted Quinazolinones

Heravi M., Montazeri N., Rahimzadeh M., Bakavoli M., Ghassemzadeh M.

Polish Journal of Chemistry

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2004

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Vol.78 /nr 11-12

2101-2103

EN

Anthranilic acid reacts with aromatic nitriles in the presence of potassium tert-butoxide to form 2-arylsubstituted quinazolinones in good yields.

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Badania ekstrakcji jonów chromu (III) kwasem antranilowym w układach siarczanowych

Kalembkiewicz J.

Zeszyty Naukowe Politechniki Rzeszowskiej. Chemia

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1998

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z. 15 [169]

17-25

PL

Zbadano ekstrakcję jonów chromu (III) w układach dwufazowych typu kwas antranilowy-toluen-woda (H+, Na+, SO2-/4); I=0,5. Określono warunki wydzielania jonów chromu (III) w badanych układach, podano skład kompleksów chromu (III) w fazie organicznej i opisano równaniami równowagi ekstrakcyjne.

EN

It was carried out the extraction of chromium (III) ions in two-phase systems: anthranilic acid-toluene-water (H+, Na+, SO2-/4); I=0,5. The conditions of separation of chromium(III) ions in examined systems were determined. The composition of chromium (III) complexes in organic phase and extraction equilibriums were described.