Wyniki wyszukiwania - BazTech

Ograniczanie wyników

Znaleziono wyników: 2

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: analytical toxicology

Sortuj według:

Ogranicz wyniki do:

A review on advances and perspectives of glyphosate determination : challenges and opportunities

Kocadal Kumsal, Alkas Fehmi Burak, Battal Dilek, Saygi Sahan

Archives of Environmental Protection

2022

Vol. 48, no. 3

89-98

Glyphosate is an inhibitor of the shikimate pathway in plants and the most widely used broad-spectrum herbicide. Due to the abundance of its use, there exists a necessity to measure the levels both in humans and in the environment to control the nefarious outcomes of its use. The appropriateness, selectivity, and the specificity of the employed analytical methods are crucial for the reliability of the resultant deductions when conducting biomonitoring studies on possible exposure to chemicals, whether the samples are biological or environmental in nature. The aim of this study is to evaluate the analytical techniques used to monitor glyphosate levels in human and environmental samples. A detailed web-based literature search was conducted to gather data on the analytical techniques used for glyphosate determination. The most preferred authentic samples are blood, urine, and milk. Environmental samples include plants, soil, and water. Among widely used analytical techniques used to detect glyphosate are High Performance Liquid Chromatography, Liquid Chromatography with tandem mass spectrometry, Gas Chromatography – Tandem Mass Spectrometry, and enzyme-linked immunosorbent assay. Depending on the sample and study, the most suitable analytical method has been selected. A critical evaluation and publication of pre-existing literature on analytical methods in glyphosate-based herbicide detection will thus aid all relevant researchers in the determination of an appropriate, selective, and specific methodology.

Application of gas chromatography with NPD detection to the analysis of tricyclic antidepressants in blood

Chłobowska Z., Chudzikiewicz E., Kościelniak P., Piekoszewski W., Stolarz A.

Chemia Analityczna

2003

Vol. 48, No. 2

255-263

Seven tricyclic antidepressants being most frequently used in Poland: imipramine, desi-pramine, clomipramine, amitriptyline, nortriptyline, doxepin and desmethyldoxepin were examined by means of gas chromatography. An extraction procedure was developed in order to separate these compounds from blood with satisfactory recovery. The chromatogra-phic analysis with NPD detection was performed, which allowed the analytes to be identified in concentrations lower than therapeutic. It was also demonstrated that NPD detector is not very sensitive to the blood matrix constituents. The optimum conditions to provide satisfactory precision of the method in the wide determination range were defined as well.

Siedem najczęściej stosowanych w Polsce trójpierścieniowych leków antydepresyjnych: imipraminę, dezipraminę, klomipraminę, amitryptylinę, nortryptylinę, doksepinę i nordokse-pinę, badano metodą chromatografii gazowej. Opracowano proces ekstrakcji tych związków, pozwalający na ich wyodrębnianie z krwi z zadowalającą wydajnością. Pomiary chromatograficzne wykonywano przy użyciu detektora NPD, co stworzyło możliwość identyfikacji badanych analitów w stężeniach mniejszych od stężeń terapeutycznych. Wykazano ponadto, że detektor ten jest mało czuły na obecność składników matrycy biologicznej krwi. Określono również warunki zapewniające uzyskiwanie wyników analitycznych z dostatecznie dużą precyzją w szerokim zakresie oznaczalności.