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Statherin and its shortened analogues

Wojciechowska I., Kochańska B., Stelmańska E., Knap N., Maćkiewicz Z., Kupryszewski G.

Polish Journal of Chemistry

1998

Vol. 72, nr 9

2098-2102

Statherin is a 43-amino acid residue phosphominiprotein present in human parotid and submandibular saliva. It may take part in transport of calcium and phosphate and most probably is partly responsible for the protection and recalcification of tooth enamel. The solid phase synthesis of statherin and its three shorttened analoques: (1-15)statherin, [Ser(2), Ser(3)](1-15) statherin and [Asp(2), Asp(3)](1-15) statherin is presented. It was established that polyclonal antibodies directed against three shortened analoques showed affinity to synthetic statherin and statherin in saliva.