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1 Journal of Medical Informatics & Technologies

1 2011

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Estimation of significance of AlkB and AlkA proteins in DNA repair in Escherichia coli model

Sokołowska B., Maciejewska A. M., Jóźwik A., Kuśmierek J. T.

Journal of Medical Informatics & Technologies

2011

Vol. 17

321--326

The paper concerns estimation of significance of differences of mutagenesis level between the wild-type strain (wt) and its derivatives which differ in DNA repair ability, namely alkA and alkB strain, devoided AlkA glycosylase and AlkB dioxygenase activity, respectively. The strains were analyzed for their ability to repair 1,N6-ethenoadenine (εA) - chloroacetaldehyde adduct to DNA. The analysis was done using classical statistical and pattern recognition methods. The obtained results confirmed that AlkB dioxygenase plays the most important role in εA repair in E. coli in the experimental modeling.