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1 International Letters of Chemistry, Physics and Astronomy

1 2013

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Development and validation of spectrophotometric methods for the quantification of solifenacin succinate: application to tablet dosage forms

Seshamamba B. S. V., Satyanarayana P. V. V., Sekaran Ch. B.

International Letters of Chemistry, Physics and Astronomy

2013

Vol. 10, iss. 2

167-182

Four sensitive, precise and accurate spectrophotometric methods for the estimationof solifenacin succinate(SFS) have been developed. Method Adescribes the interaction of SFSwith potassium permanganate in alkaline mediumto give green colored manganate ionwith absorption maxima at 610nm. Methods Band Care based on the formation of ternary complexes of SFSwith, copper (II)/eosin(method B)and ammonium molybdate/ammonium thiocyanate(method C),respectivelywhich are extracted into chloroform and have absorption maxima at 545nm (method B) and 465nm (method C). Method D was based on the formation of yellowcolored ion-pair complex between bromocresol green and SFS in dichloromethane medium with absorption maxima at 415nm.Regression analysis of Beer's law plot showed good correlation in the concentration range of 5-50, 2.5-50, 10-100 and 2-20 μg/mLfor methods A, B, Cand D, respectively. Different variables affecting the reaction were studied and optimized. The proposed methods were applied successfully for the analysis of SFSin tablets dosage forms. No interference was observed from common pharmaceutical excipients.