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Metody syntezy 2,2'-bipirolidyny

Eichstaedt K.

Wiadomości Chemiczne

2012

[Z] 66, 5-6

461-483

Vicinal diamine derivatives form an interesting and significant class of organic compounds. They play an essential role as chelating agents and also as ligands for asymmetric synthesis. They are used in synthesis of biologically active substances and in supramolecular chemistry [1–11]. There has been published a great number of reviews concerning the application and synthesis of 1,2-diamines with special emphasis on their organic potential [1–11]. Without any doubt, chiral 2,2’- bipyrrolidine derivatives are representative family of these compounds. They have gained particular attention since they are widely used. A remarkably broad spectrum of synthetic exploration has been reported for these agents [4, 12–14]. This paper provides description of methods for the synthesis of chiral 2,2’-bipyrrolidine. There are only seven different approaches to obtain (R,R) or (S,S)-2,2’-bipyrrolidine, five from which take advantage of stereoselective synthesis steps [15–21]. Nevertheless, a method for the synthesis of amine-1, which connects low reagents price with low time-consuming and high yield have not been described yet. Thus, creation of a new strategy for an efficient synthesis of chiral 2,2’-bipyrrolidine is still a challenging topic of studies.