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1-(2,4-Dinitrophenyl)-5-nitrouracil a Versatile Reagent for the Synthesis of N1-Modified Uracil Derivatives

Gondela A., Sroka M., Walczak K.

Polish Journal of Chemistry

2007

Vol. 81, nr 12

2143-2149

1-(2,4-Dinitrophenyl)-5-nitrouracil has been used as a substrate in reactions with a number of compounds possessing primary amino groups such as: amino alcohols, aminodiols, esters of amino ac ids and benzylamines. As a result of regioselective course of performed reactions the series of 5-nitro-1-substituted uracils were obtained. All newly synthesized compounds were subjected to primary bioactivity as says as inhibitors against Mycobacterium tuberculosis; two of them exhibited inhibition ability.